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Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy
Anaplastic thyroid cancer is an extremely aggressive disease resistant to radioiodine treatment because of loss of sodium iodide symporter (NIS)...
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Synthesis of magnetic resonance–, X-ray– and ultrasound-visible alginate microcapsules for immunoisolation and noninvasive imaging of cellular therapeutics
Cell therapy has the potential to treat or cure a wide variety of diseases. Non-invasive cell tracking techniques are, however, necessary to...
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Evaluation of a Multi-pinhole Collimator for Imaging Small Animals with Different Sizes
PurposeOur goal was to evaluate a multi-pinhole (MPH) collimator which allows changing configurations for mouse imaging and rat imaging.
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Post-lumpectomy intracavitary retention and lymph node targeting of 99mTc-encapsulated liposomes in nude rats with breast cancer xenograft
Liposomes are recognized drug delivery systems with tumor-targeting capability. In addition, therapeutic or diagnostic radionuclides can be...
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A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer
The sodium iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells. We have extended the use of NIS-mediated...
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Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts
PurposeTo investigate the effect of intratumoral administration of collagenase-2 on liposomal drug accumulation and diffusion in solid tumor...
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What Is Wrong with Digital Documents? A Conceptual Model for Structural Cross-Media Content Composition and Reuse
Many of today’s digital document formats are strongly based on a digital emulation of printed media. While such a paper simulation might be... -
Development and Validation of a Monte Carlo Simulation Tool for Multi-Pinhole SPECT
PurposeIn this work, we developed and validated a Monte Carlo simulation (MCS) tool for investigation and evaluation of multi-pinhole (MPH) SPECT...
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An Architecture for Open Cross-Media Annotation Services
The emergence of new media technologies in combination with enhanced information sharing functionality offered by the Web provides new possibilities... -
Bisphosphonate Delivery to Tubular Bone Allografts
Large structural allografts used for reconstruction of bone defects after revision arthroplasty and tumor resection fracture up to 27% of the time...
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Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media
PurposeA procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186 Re-liposomes in tumoral tissue, using HS...
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An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles
Nanomaterials have become increasingly important in the development of new molecular probes for in vivo imaging
1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 , both experimentally... -
Towards the Development of Open Cartographic Hypermedia Systems
Despite the evolving technological developments that have influenced spatial information management and communication, digital cartography has to... -
Accessing Related Web Resources Through Annotated Documents
This paper proposes a new framework for organizing and accessing Web resources using loci defined on arbitrary Web documents. Our framework allows... -
A New Method for SPECT Quantification of Targeted Radiotracers Uptake in the Myocardium
We developed a new method for absolute quantification of targeted radiotracers uptake in the myocardium using hybrid SPECT/CT and an external... -
Hot plasmas in space: X-ray diagnostic instrumentation
A new era of X-ray astrophysics began when the imaging and spectral data from ROSAT and ASCA became available. The information content of cosmic... -
Replicated Reflectors for Wide Field X-Ray Imaging Telescopes
At energies between 0.1 and 10 keV, wide-field imaging can be achieved by lobster-eye type reflecting X-ray optics. We summarize possible approaches...