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Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
The adenosine A 1 receptor (A 1 R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain
1 ,2 . However, development...
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Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke
Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The...
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Inhibition of CSPG-PTPσ Activates Autophagy Flux and Lysosome Fusion, Aids Axon and Synaptic Reorganization in Spinal Cord Injury
Chondroitin sulfate proteoglycans (CSPGs) and proteoglycan receptor protein tyrosine phosphatase σ (PTPσ) play a critical role in the pathology of...
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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2
Hexahydro-1,3,5-trinitro-1,3,5-triazine, or Royal Demolition Explosive (RDX), is a major component of plastic explosives such as C-4. Acute exposures...
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Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca 2+ sparks constitute the fundamental units of Ca 2+ release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively...
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Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators
Inhibition of tumor necrosis factor receptor 1 (TNFR1) is a billion-dollar industry for treatment of autoimmune and inflammatory diseases. As current...
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A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine
The children of obese mothers are known to have a high risk of obesity and metabolic disease and are prone to develo** cognitive deficits, although...
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TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes
BackgroundT cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to...
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MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
Metastasis Associated in Colon Cancer 1 (MACC1) is a novel prognostic, predictive and causal biomarker for tumor progression and metastasis in many...
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Asymmetric activation of the calcium-sensing receptor homodimer
The calcium-sensing receptor (CaSR), a cell-surface sensor for Ca 2+ , is the master regulator of calcium homeostasis in humans and is the target of...
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Structural insights on ligand recognition at the human leukotriene B4 receptor 1
The leukotriene B4 receptor 1 (BLT1) regulates the recruitment and chemotaxis of different cell types and plays a role in the pathophysiology of...
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Immune inhibitory receptor-mediated immune response, metabolic adaptation, and clinical characterization in patients with COVID-19
Immune inhibitory receptors (IRs) play a critical role in the regulation of immune responses to various respiratory viral infections. However, in...
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Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells
Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown...
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DIISCO: A Bayesian Framework for Inferring Dynamic Intercellular Interactions from Time-Series Single-Cell Data
Characterizing cell-cell communication and tracking its variability over time is essential for understanding the coordination of biological processes...
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Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor
RyR1 is an intracellular Ca 2+ channel important in excitable cells such as neurons and muscle fibers. Ca 2+ activates it at low concentrations and...
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Quantitative structure–activity relationship modeling of hydroxylated polychlorinated biphenyls as constitutive androstane receptor agonists
Hydroxylated polychlorinated biphenyls (OH-PCBs), a series of toxic chemical compounds produced via biotic and abiotic transformation of...
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Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies
Invasion of human erythrocytes by Plasmodium falciparum ( Pf ) merozoites relies on the interaction between two parasite proteins: apical membrane...
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Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants
Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain...
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The Ambiguity Issue in Solving Inverse Problems of Small-Angle Scattering: A Consistent Approach Using an Insulin Receptor-Related Receptor as an Example. Methods for Interpreting SAXS Data
AbstractThe construction of three-dimensional models of protein macromolecules is a serious challenge due to the possible ambiguity of solving the...
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently...
