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Characterization of adaptive expression regulation of yellowtail kingfish (Seriola lalandi) leptin, receptor, and receptor overlap** transcript genes in response to fasting and re-feeding strategies
Leptins and other related genes have been proven to play vital roles in food intake, weight control, and other life activities. While the function of...
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Transcriptome profiling of longissimus dorsi during different prenatal stages to identify genes involved in intramuscular fat deposition in lean and obese pig breeds
BackgroundThere was significant difference in muscle development between fat-type and lean-type pig breeds.
Methods and resultsIn current study,...
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Early expression onset of tissue-specific effector genes during the specification process in sea urchin embryos
BackgroundIn the course of animal developmental processes, various tissues are differentiated through complex interactions within the gene regulatory...
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Identification, characterization, and prognosis investigation of pivotal genes shared in different stages of breast cancer
One of the leading causes of death (20.1 per 100,000 women per year), breast cancer is the most prevalent cancer in females. Statistically, 95% of...
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Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways
SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in the airway epithelium. The similarities and...
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TRIM28 modulates nuclear receptor signaling to regulate uterine function
Estrogen and progesterone, acting through their cognate receptors the estrogen receptor Ī± (ERĪ±) and the progesterone receptor (PR) respectively,...
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GNRH family genes contributed to gender-specific disparity of bladder cancer prognosis through exerting opposite regulatory roles between males and females
PurposeThere is gender-specific disparity in bladder cancer (BlCa) prognosis. Female BlCa patients present with more advanced tumor and have higher...
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MicroRNA-561-3p indirectly regulates the PD-L1 expression by targeting ZEB1, HIF1A, and MYC genes in breast cancer
Globally, breast cancer is the second most common cause of cancer-related deaths among women. In breast cancer, microRNAs (miRNAs) are essential for...
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Identification of key genes of anti-programmed death ligand 1 for meningioma immunotherapy by bioinformatic analysis
Meningioma is one of the most common primary tumors in the central nervous system (CNS). A deeper understanding of its molecular characterization...
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Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR
Transcriptional regulator MtrR inhibits the expression of the multidrug efflux pump operon mtrCDE in the pathogenic bacterium Neisseria gonorrhoeae ....
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Co-regulation of circadian clock genes and microRNAs in bone metabolism
Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone...
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Meta-analysis highlights the key drought responsive genes in genes: PEPC and TaSAG7 are hubs response networks
BackgroundWheat is the most important cereal. One of the environmental stresses is drought that harm the production of many cereals and every year...
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Response of Therapy in Cell-Cycle Regulatory Genes in Breast Cancer
Dysregulation of the cell cycle, which permits for unrestricted cellular division, is a characteristic of cancer. Cells develop genetic changes that...
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Dax1 modulates ERĪ±-dependent hypothalamic estrogen sensing in female mice
Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to...
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Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome
Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental...
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Glycometabolism and lipid metabolism related genes predict the prognosis of endometrial carcinoma and their effects on tumor cells
BackgroundGlycometabolism and lipid metabolism are critical in cancer metabolic reprogramming. The primary aim of this study was to develop a...
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Molecular Targets for Nonhormonal Treatment Based on a Multistep Process of Adenomyosis Development
Adenomyosis is an estrogen-dependent gynecologic disease characterized by the presence of endometrial tissue within the myometrium. Adenomyosis...
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FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
BackgroundObesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive...
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Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
AbstractStress can play a significant role in arterial hypertension and many other complications of cardiovascular diseases. Considerable attention...
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Phytocompounds From Edible Oil Seeds Target Hub Genes To Control Breast Cancer
Breast cancer is one of the most commonly diagnosed cancers in woman which accounts for more than 1 in 10 new cancers in the entire world. The...
