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Constructing lncRNA-miRNA-mRNA networks specific to individual cancer patients and finding prognostic biomarkers
BackgroundThe competitive endogenous RNA (ceRNA) hypothesis suggests that microRNAs (miRNAs) mediate a regulatory relation between long noncoding...
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Trimethylamine-N-oxide, a New Risk Factor for Non-alcoholic Fatty Liver Disease Changes the Expression of miRNA-34a, and miRNA-122 in the Fatty Liver Cell Model
Non-alcoholic fatty liver disease is a multifactorial disorder with complicated pathophysiology ranging from simple steatosis to steatohepatitis and...
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MiRNA-30a-5p/VCAN Arrests Tumor Metastasis via Modulating the Adhesion of Lung Adenocarcinoma Cells
Previous research indicated that the dysregulation of miRNA-30a-5p has a correlation with cell metastasis of lung adenocarcinoma (LUAD). But the...
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Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every...
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Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies
MicroRNAs (miRNAs) are small non-coding RNA molecules that play pivotal roles in regulating gene expression and have been implicated in the...
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Identification of circRNA–miRNA–mRNA regulatory network associated to the autism spectrum disorder in children through integrated bioinformatics analysis
BackgroundAutism spectrum disorder (ASD) is a complex neurological disability with multifactorial etiology. ASD is described by behavior, speech,...
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Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma
BackgroundThe growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms...
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Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC Model
The pathogenesis of diabetes involves complex changes in the expression profiles of mRNA and non-coding RNAs within pancreatic islet cells. Recent...
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Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke
Molecule alterations are important to explore the pathological mechanism of ischemic stroke (IS). Ferroptosis, a newly recognized type of regulated...
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Comprehensive analysis of miRNA-mRNA regulatory pairs associated with colorectal cancer and the role in tumor immunity
BackgroundMicroRNA (miRNA) which can act as post-transcriptional regulators of mRNAs via base-pairing with complementary sequences within mRNAs is...
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miRNA profiling of chicken follicles during follicular development
MicroRNAs (miRNAs) play a crucial role as transcription regulators in various aspects of follicular development, including steroidogenesis,...
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RNA in Gene Regulation
According to the central dogma of molecular biology, DNA stores genetic information and RNA transmits the genetic information. RNA plays an important...
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MiRNA-related metastasis in oral cancer: moving and shaking
Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and incidence have grown. Oral cancer metastasis is a complex...
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Inferring pseudogene–MiRNA associations based on an ensemble learning framework with similarity kernel fusion
Accumulating evidence shows that pseudogenes can function as microRNAs (miRNAs) sponges and regulate gene expression. Mining potential interactions...
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Assessment of Cell Cytotoxicity in 3D Biomaterial Scaffolds Following miRNA Transfection
Assessment of cell cytotoxicity following transfection of cells with microRNA (miRNA) is an essential step in the evaluation of basic miRNA...
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DNI-MDCAP: improvement of causal MiRNA-disease association prediction based on deep network imputation
BackgroundMiRNAs are involved in the occurrence and development of many diseases. Extensive literature studies have demonstrated that miRNA-disease...
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Plasma exosomes lncRNA-miRNA-mRNA network construction and its diagnostic efficacy identification in first-episode schizophrenia
BackgroundThe exosomal lncRNA-miRNA-mRNA networks in first episode schizophrenia (FOS) have not reported yet. This study examined the lncRNA, miRNA...
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FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in...
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Integrative bioinformatics analysis of miRNA and mRNA expression profiles identified some potential biomarkers for breast cancer
BackgroundBreast cancer is a common cause of cancer death among women with a complex and heterogeneous picture in histological, molecular and...
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EMCMDA: predicting miRNA-disease associations via efficient matrix completion
Abundant researches have consistently illustrated the crucial role of microRNAs (miRNAs) in a wide array of essential biological processes....
