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Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus
Loss of cardiomyocytes due to apoptotic or necrotic death is an important component of the pathogenesis of heart failure. Initiation of apoptosis by...
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FK506-binding protein 2 (FKBP13) inhibit Bax-induced apoptosis in Saccharomyces cerevisiae (yeast)
FK506-binding protein 2 (FKBP13) is a part of the immunophilin protein family involved in immunoregulation. It is also believed to operate as a...
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The role of FASL, BCL-2 and BAX polymorphisms in brazilian patients with prostate cancer and benign prostatic hyperplasia
BackgroundProstate cancer (PCA) is one of the leading causes of death among men, being related to several factors, including the aging male...
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The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis
ObjectiveElamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and...
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Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia
The present study investigated, the anti-apoptotic activity of Ginsenoside Rg1 (Rg1) via inhibition of Bax translocation and the subsequent recovery...
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Altered Expressions of PTEN, p53, Bax and Bcl-2 Genes by a Bioactive Pigment from Streptomyces sp. JUA14 Mediate Apoptosis of Cancer Cells
AbstractCancer is one of the leading causes of death around the world with major side effects for existing therapies. The current study was aimed to...
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Elevated Bax/Bcl-2 Ratio: A Cytotoxic Mode of Action of Kermanian Propolis Against an Acute Lymphoblastic Leukemia Cell Line, NALM-6
Currently, alternative cancer remedies, especially herbal-derived medicines, have attracted great interest. Propolis, a honeybee-produced...
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Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2
Mitochondrial mass imbalance is one of the key causes of cardiovascular dysfunction after hypoxia. The activation of dynamin-related protein 1...
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BAX and SMAC regulate bistable properties of the apoptotic caspase system
The initiation of apoptosis is a core mechanism in cellular biology by which organisms control the removal of damaged or unnecessary cells. The...
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The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer
Although radiation-induced bystander effects have been broadly explored in various biological systems, the molecular mechanisms and the consequences...
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Amaranthus viridis methanolic extract and its active compound kaempferol ameliorate myocardial infarction induced by isoproterenol through decreasing oxidative stress and cell death via Nrf-2/HO-1 and MMP/Bax/Bcl-2/TLR-4 pathways in rats
The cardioprotective impact of Amaranthus viridis methanolic extracts (AVMEs) and its active phytoconstituent kaempferol on isoproterenol...
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Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis
Recent advancements in live cell imaging technologies have identified the phenomenon of intracellular propagation of late apoptotic events, such as...
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EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX
Early growth response (EGR) proteins have been reported to be involved in cell growth and apoptosis in a variety of cancer types and could inhibit...
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Antibacterial potential and cytotoxic activity of iron oxide nanoparticles conjugated with thymol (Fe3O4@Glu-Thymol) on breast cancer cells and investigating the expression of BAX, CASP8, and BCL-2 genes
The use of metal nanoparticles (NPs) conjugated with natural herbal molecules in biomedical applications has been growing. In this work, we...
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The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats
BackgroundMethotrexate (MT) is a broadly used chemotherapeutic drug however its clinical use is confronted with several forms of toxicities...
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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv. oryzae
The hypersensitive response (HR) is a form of programmed cell death of plant cells occurring in the local region surrounding pathogen infection site...
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Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak
The ability of mitochondria to buffer a rapid rise in cytosolic Ca 2+ is a hallmark of proper cell homeostasis. Here, we employed m-3M3FBS, a putative...
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Upregulation of Bax, TNF-α and down-regulation of Bcl-2 in liver cancer cells treated with HL-7 and HL-10 peptides
Nowadays, cancer has become a pervasive disease in the world. Due to the side effects of chemotherapeutic agents, the use of peptides has been...
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Synthesize of Bi2O3/Gln-TSC nanoparticles and evaluation of their toxicity on prostate cancer cells and expression of CASP8, BAX, and Bcl-2 genes
Due to the high prevalence and considerable increase of prostate cancer, finding novel therapeutic compounds for the treatment of prostatic cancer...
