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Gastrointestinal involvement in STEC-associated hemolytic uremic syndrome: 10 years in a pediatric center
BackgroundThe gastrointestinal (GI) tract represents one of the main targets of typical hemolytic uremic syndrome (HUS) in children. In this...
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A phase IV study evaluating QT interval, pharmacokinetics, and safety following fractionated dosing of gemtuzumab ozogamicin in patients with relapsed/refractory CD33-positive acute myeloid leukemia
PurposeGemtuzumab ozogamicin (GO) is indicated for treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML). The QT interval,...
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History and current standard of postnatal management in hemolytic disease of the fetus and newborn
Since the discovery of the Rh blood group system in 1940, a greater understanding of hemolytic disease of the fetus and newborn (HDFN) was gained. In...
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Hereditary nonspherocytic hemolytic anemia caused by glucose-6-phosphate isomerase (GPI) deficiency in a Chinese patient: a case report
BackgroundGlucose phosphate isomerase (GPI) deficiency is a rare autosomal recessive disorder that causes hereditary nonspherocytic hemolytic anemia...
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Models of bilirubin neurological damage: lessons learned and new challenges
ObjectiveJaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the tissue and is indicative of potential toxicity to...
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Enhanced Hemocompatibility of Lysine Grafted Polyacrylonitrile Electrospun Nanofiber Membranes as a Potential Bilirubin Adsorption in Hemoperfusion
Hyperbilirubinemia is one of most severe clinical diseases, which is caused by the accumulation of unconjugated bilirubin. Electrospun nanofiber...
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Population-based incidence and risk factors for cholestasis in hemolytic disease of the fetus and newborn
ObjectiveTo estimate the incidence of cholestasis in neonates with hemolytic disease of the fetus and newborn (HDFN) and investigate risk factors and...
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Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling
Neonatal jaundice is one of the most common disorders in the first 2 wk after birth. Unconjugated bilirubin (UCB) is neurotoxic and can cause...
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A de novo ANK1 mutation in a childhood hereditary spherocytosis: a case report
BackgroundDue to the heterogeneity of the phenotype of Hereditary spherocytosis (HS) patients, some patients may have rare clinical complications...
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Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate
High consumption of locally produced delicacies could expose nursing mothers to high monosodium glutamate (MSG) levels, frequently used as a...
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Deep Learning Approach for Early Diagnosis of Jaundice
Jaundice is a yellow discoloration of the body caused by an increased level of bilirubin. Globally, newborns and adults are both affected by this...
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An Unusual Presentation: Prolonged Jaundice Associated with Infantile Hypertrophic Pyloric Stenosis. A Case Report
Infantile hypertrophic pyloric stenosis is a disorder that causes a near-complete occlusion of the gastric outflow and leads to forceful vomiting in...
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Solvent fractions of Vitellaria paradoxa root extract suppress phenylhydrazine-mediated jaundice in Wistar rats
BackgroundIn the first few days of life, jaundice has continued to be a major health concern. It typically manifests as a yellowing of the skin,...
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Irradiance footprint of phototherapy devices: a comparative study
BackgroundPhototherapy (PT) is the standard treatment of neonatal unconjugated hyperbilirubinemia. The irradiance footprint, i.e., the illuminated...
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Surgical Jaundice and Cholangitis
Jaundice may result from various illnesses, among which obstruction of the biliary tree is the main surgical focus. Cholangitis is generally...
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Inhibition of Microglial Activation Ameliorates Inflammation, Reduced Neurogenesis in the hippocampus, and Impaired Brain Function in a Rat Model of Bilirubin Encephalopathy
Hyperbilirubinemia is one of the most common occurrence in newborns and is toxic to the brain, resulting in neurological sequelae such as auditory...
