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Comparative Analysis of Supervised Cell Type Detection in Single-Cell RNA-seq Data
Recent studies on Single-cell RNA sequencing (scRNA-seq) technology have been widely applied in biological research and drug discovery. Before...
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Case 34: Typical AD with Discordant Biomarkers
A 59-year-old female with a clinical history (4 years) of mild cognitive impairment with long-term (episodic and autobiographic) and short-term...
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Novel insight into ferroptosis-related genes, molecular subtypes, and immune characteristics in intracranial aneurysms
ObjectivesThis study aimed to identify the role of ferroptosis in intracranial aneurysm (IA).
MethodsGSE122897, GSE75436, GSE15629, and GSE75434...
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Gene correlation network analysis to identify regulatory factors in sciatic nerve injury
BackgroundSciatic nerve injury (SNI), which frequently occurs under the traumatic hip and hip fracture dislocation, induces serious complications...
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Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes...
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APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer
BackgroundRecent studies have demonstrated that APOC1 is associated with cancer progression, exerting cancer-promoting and immune...
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Identification of unique genomic signatures in patients with fibromyalgia and chronic pain
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain. The pathophysiology of fibromyalgia is not clearly understood and...
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A prognostic gene signature for gastric cancer and the immune infiltration-associated mechanism underlying the signature gene, PLG
BackgroundGlobally, gastric cancer (GC) is a common and lethal solid malignant tumor. Identifying the molecular signature and its functions can...
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Differentiated Embryonic Neurospheres from Familial Alzheimer’s Disease Model Show Innate Immune and Glial Cell Responses
Proteins involved in the Alzheimer’s disease (AD), such as amyloid precursor protein (APP) and presenilin-1 (PS1), play critical roles in early...
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A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism
BackgroundOsteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and...
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Fibrin-Targeting Immunotherapy for Dementia
Blood-brain barrier (BBB) disruption is an early event in the development of Alzheimer’s disease. It precedes extracellular deposition of amyloid-β...
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As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer’s Disease
C1q, the initiator of the classical pathway of the complement system, is activated during Alzheimer’s disease (AD) development and progression and is...
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The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterization
BackgroundCirculating tumor cells (CTCs) are important for metastatic dissemination of cancer. They can provide useful information, regarding...
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TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain
Aging decreases cognitive functions, especially learning and memory. Neuroinflammation is mediated by microglia and occurs in age-related...
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Bioinformatics analysis of C3 and CXCR4 demonstrates their potential as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC)
BackgroundThe molecular prognostic biomarkers of clear cell renal cell carcinoma (ccRCC) are still unknown. We aimed at researching the candidate...
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Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
Backgroundp16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found...
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau...
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Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators....
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Cholesterol lowering depletes atherosclerotic lesions of smooth muscle cell-derived fibromyocytes and chondromyocytes
Drugs that lower plasma apolipoprotein B (ApoB)-containing lipoproteins are central to treating advanced atherosclerosis and provide partial...
