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PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity
Dendritic cells (DC) are traditionally classified according to their ontogeny and their ability to induce T cell response to antigens, however, the...
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Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy
BackgroundCellular senescence is growing in popularity in cancer. A dual function is played by the senescence-associated secretory phenotype (SASP)...
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Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci
Casparian strips (CS) are aligned bands of lignin-impregnated cell walls, building an extracellular diffusion barrier in roots. Their structure...
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Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype
HuD, an RNA binding protein, plays a role in the regulation of gene expression in certain types of cells, including neuronal cells and pancreatic...
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High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology
We report 2 cases of high-grade sinonasal adenocarcinoma with a distinct morphological and immunohistochemical phenotype. Albeit histologically...
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The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts
We have shown previously that the lysosomal a3 isoform of the a subunit of vacuolar-type ATPase (V-ATPase) interacts with inactive (GDP-bound form)...
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Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells
The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “ stimulus-secretion coupling ”. The core of...
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Molecular Cloning and Functional Analysis of Secretory Phospholipase A2 from Apostichopus japonicus
Secretory phospholipase A 2 (sPLA 2 ) plays important roles in phospholipid metabolism, skin barrier maintenance, immune response and other processes in...
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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling
Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression....
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Human distal airways contain a multipotent secretory cell that can regenerate alveoli
The human lung differs substantially from its mouse counterpart, resulting in a distinct distal airway architecture affected by disease pathology in...
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Targeted gene expression profiling for accurate endometrial receptivity testing
Expressional profiling of the endometrium enables the personalised timing of the window of implantation (WOI). This study presents and evaluates a...
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A host-vector toolbox for improved secretory protein overproduction in Bacillus subtilis
AbstractTarget proteins in biotechnological applications are highly diverse. Therefore, versatile flexible expression systems for their functional...
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The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role
BackgroundCryptosporidium parvum is a zoonotic parasite and member of the phylum Apicomplexa with unique secretory organelles, including a rhoptry,...
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The Role of Metaflammation in the Development of Senescence-Associated Secretory Phenotype and Cognitive Dysfunction in Aging Mice
AbstractAging is accompanied by the triggering of numerous pathophysiological events, which include inflammation, cellular senescence and...
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Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi,...
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S-100 Protein-Negative Secretory Breast Carcinoma: Case Report of a Rare Entity
Secretory breast carcinoma represents a rare subtype within basal-like tumours of the breast, having an excellent prognosis, in stark contrast with...
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Proteomic differences between extracellular vesicles and extracellular vesicle-depleted excretory/secretory products of barber’s pole worm
BackgroundComponents of excretory/secretory products (ESPs) of helminths have been proposed as vaccine targets and shown to play a role in modulating...
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Trichinella spiralis excretory/secretory products from adult worms inhibit NETosis and regulate the production of cytokines from neutrophils
Upon encountering exogenous pathogens, polymorphonucleocytes (PMNs) engage in various processes to destroy them, including releasing neutrophil...
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High Cell-Density Expression System: Yeast Cells in a Phalanx Efficiently Produce a Certain Range of “Difficult-to-Express” Secretory Recombinant Proteins
Yeast’s extracellular expression provides a cost-efficient means of producing recombinant proteins of academic or commercial interests. However,...
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Characterizing Membrane Traffic in the Early Secretory Pathway Using the RUSH Retention System
The early secretory pathway encompasses the endoplasmic reticulum (ER) and the ER–Golgi intermediate compartment (ERGIC) organelles. The ERGIC is now...