Search
Search Results
-
Presynaptic Dysfunction in Parkinson’s Disease
Parkinson’s disease (PD) is followed by neurodegeneration that causes impairment of body movement, nervous system abnormalities, and sleep disorders....
-
The Critical Role of Biomarkers for Drug Development Targeting the Biology of Aging
Alzheimer’s disease is a devastating neurodegenerative disorder that poses a significant societal burden. Approval of anti-amyloid antibody therapies...
-
Levetiracetam (LEV)
Das Kapitel zeigt tabellarisch das Kurzprofil des Medikaments Levetiracetam (LEV).
-
Monitoring synaptic pathology in Alzheimer’s disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives
Alzheimer’s disease (AD) is currently constrained by limited clinical treatment options. The initial pathophysiological event, which can be traced...
-
Brivaracetam (BRV)
Das Kapitel zeigt tabellarisch das Kurzprofil des Medikaments Brivaracetam (BRV).
-
Nuclear Medicine Imaging Tracers for Neurology
Tracers to investigate neurological disorders with positron emission tomography (PET) or single-photon emission computed tomography (SPECT) have...
-
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Seizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease....
-
Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers
PurposeSynaptic vesicle protein 2A (SV2A) serves as a biomarker of synaptic density and positron emission tomography (PET) imaging of SV2A could...
-
[18F]SynVesT-1 and [18F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II
PurposeMRI-negative children with focal cortical dysplasia type II (FCD II) are one of the most challenging cases in surgical epilepsy management. We...
-
Brivaracetam – eine gute Alternative zur Behandlung von Muskelkrämpfen
BackgroundMuscle cramps are suddenly occurring involuntary, mostly painful contractions of a single muscle, rarely of a muscle group. They can be...
-
Wirkmechanismen anfallssuppressiver Medikamente (G. Krämer)
Die Wirkmechanismen der anfallssuppressiven Medikamente sind nur teilweise aufgeklärt. Sie schließen v. a. Effekte auf spannungsabhängige Natrium-...
-
Spinocerebellar ataxia type 11 (SCA11): TTBK2 variants, functions and associated disease mechanisms
Spinocerebellar ataxia type 11 (SCA11) is a rare type of autosomal dominant cerebellar ataxia, mainly characterized by progressive cerebellar ataxia,...
-
Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue
PurposeA [ 11 C]UCB-J blocking study was performed in healthy volunteers to validate simplified, non-invasive measures for quantifying presynaptic...
-
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
-
-
-
Radiotracers for PET Imaging of the Brain
PET radiotracers are functional compounds that are labeled with positron-emitting radionuclides and identifying a tracer with specific properties is...
-
Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein...
-
Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy
IntroductionSelf-limited infantile epilepsy (SeLIE) is a benign epilepsy. Previous studies have shown that monotherapy with most antiseizure...
