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Budget Impact Analysis of Intensification with iGlarLixi Compared to Alternative Treatment Strategies Among Patients with Type 2 Diabetes Mellitus
IntroductionThe clinical benefits of treating patients with type 2 diabetes mellitus (T2DM) with fixed-ratio combination of insulin iGlar (iGlar)...
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Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects
BackgroundPrescribing information instructs taking oral semaglutide (a glucagon-like peptide-1 analogue) in the fasting state, followed by a...
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A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects
Biotherapeutics are highly efficacious, but the pain and inconvenience of chronic injections lead to poor patient compliance and compromise effective...
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Outpatient Management of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a common chronic disease affecting an increasingly younger population and imposing a high burden and cost to the... -
Antipsychotic-Induced Weight Gain in Severe Mental Illness: Risk Factors and Special Considerations
Purpose of ReviewWeight gain is a disconcerting issue experienced by patients treated with antipsychotics (APs). This review summarizes current...
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Glucagon-like Peptide-1 Receptor Agonists
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) have been used to treat patients with type 2 diabetes mellitus (T2DM) since exenatide,... -
Semaglutide and Diabetic Retinopathy Risk in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials
BackgroundSemaglutide is a recently approved glucagon-like peptide-1 receptor agonist used to treat patients with type 2 diabetes mellitus (T2DM)....
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A Review on Forced Degradation Strategies to Establish the Stability of Therapeutic Peptide Formulations
Peptides are small polymers composed of 40 or fewer amino acids and are an increasingly important class of drugs. Therapeutic peptides are less...
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The Impact of the Priority Review Voucher on Research and Development for Tropical Diseases
BackgroundIn 2007, the priority review voucher (PRV) was implemented in the US to incentivize research and development (R&D) for tropical diseases....
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From Ideation to Innovation: Integrating Pharmaceutical Innovation and Sustainable Development
In recent years, there has been a growing focus on sustainability in the pharmaceutical industry by policymakers, consumers, and organizations. This...