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Prognostic and predictive biomarkers for response to neoadjuvant chemoradiation in esophageal adenocarcinoma
BackgroundEsophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the...
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Selection of Patients for Organ Preservation After Chemoradiotherapy: MRI Identifies Poor Responders Who Can Go Straight to Surgery
ObjectiveThe aim of this study was to evaluate whether magnetic resonance imaging (MRI) can accurately identify poor responders after...
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Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma
Anti-programmed cell death-1 (anti-PD-1) therapies have shown a favorable efficacy and good tolerance for relapsed or refractory (r/r) classical...
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Recognition of 7 genes signature (Cirrhosis Risk Score) in the diagnosed non-responders to DAAs therapy by intra-PBMCs nested HCV RNA PCR
Background and aimsPredictors of chronic HCV response to oral antiviral therapy (OAT) are related to host genetic variations. Single nucleotide...
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Improved Outcomes for Responders After Treatment with Induction Chemotherapy and Chemo(re)irradiation for Locally Recurrent Rectal Cancer
BackgroundDespite improvements in the multimodality treatment for patients with locally recurrent rectal cancer (LRRC), oncological outcomes remain...
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Pathologic response of ductal carcinoma in situ to neoadjuvant systemic treatment in HER2-positive breast cancer
PurposeThe presence of extensive ductal carcinoma in situ (DCIS) adjacent to HER2-positive invasive breast cancer (IBC) is often a contra-indication...
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Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial
Overall survival (OS) benefits of neoadjuvant immunotherapy remain elusive in locally advanced esophageal squamous cell carcinomas (ESCC). Here, we...
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A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer
Patients with hormone receptor (HR)-positive tumors breast cancer usually experience a relatively low pathological complete response (pCR) to...
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Neoadjuvant Afatinib for stage III EGFR-mutant non-small cell lung cancer: a phase II study
Afatinib, an irreversible ErbB-family blocker, could improve the survival of advanced epidermal growth factor receptor ( EGFR )-mutant non-small cell...
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Top Colorectal Articles from 2021 to Inform Your Cancer Practice
Multimodality treatment for locally advanced rectal cancer is the standard of care. Treatments include surgery, radiation, and chemotherapy, with...
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Blood-based molecular and cellular biomarkers of early response to neoadjuvant PD-1 blockade in patients with non-small cell lung cancer
BackgroundDespite the improved survival observed in PD-1/PD-L1 blockade therapy, a substantial proportion of cancer patients, including those with...
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Does Neutrophil-to-Lymphocyte Ratio (NLR) Predict Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma?
BackgroundNeoadjuvant chemoradiotherapy (nCRT), followed by surgery, is the current standard of care for patients with locally advanced esophageal...
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Is It Really Gone? Assessing Response to Neoadjuvant Therapy in Rectal Cancer
PurposeNon-operative management of rectal cancer is a feasible and appealing treatment option for patients who develop a complete response after...
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Factors affecting the value of diffusion-weighted imaging for identifying breast cancer patients with pathological complete response on neoadjuvant systemic therapy: a systematic review
This review aims to identify factors causing heterogeneity in breast DWI–MRI and their impact on its value for identifying breast cancer patients...
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Circulating microRNA-155-3p levels predicts response to first line immunotherapy in patients with metastatic renal cell carcinoma
Predictive biomarkers of response to immune checkpoint-based therapies (ICI) remain a critically unmet need in the management of advanced renal cell...
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Quantitative digital histopathology and machine learning to predict pathological complete response to chemotherapy in breast cancer patients using pre-treatment tumor biopsies
Complete pathological response (pCR) to neoadjuvant chemotherapy (NAC) is a prognostic factor for breast cancer (BC) patients and is correlated with...
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Neoadjuvant Therapy in Melanoma: Where Are We Now?
Purposeof ReviewThis review summarizes the current state of neoadjuvant immunotherapy and targeted therapy for locoregionally advanced melanoma.
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Cardiac Arrest: Pediatric Out-of-Hospital Cardiac Arrest on the Soccer Pitch—How Implementation of Digital Solutions into the Chain of Survival Can Help with a Favorable Outcome
Pediatric out-of-hospital cardiac arrest (POHCA) is rare and survival rates are poor. Improved survival and increased favorable neurological outcome...
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Recurrence of Hepatocellular Carcinoma After Complete Radiologic Response to Trans-Arterial Embolization: A Retrospective Study on Patterns, Treatments, and Prognoses
BackgroundThere is limited information about the long-term outcomes and patterns of progression in patients who have unresectable, liver-confined...
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Multiphase and multiparameter MRI-based radiomics for prediction of tumor response to neoadjuvant therapy in locally advanced rectal cancer
BackgroundTo develop and validate radiomics models for prediction of tumor response to neoadjuvant therapy (NAT) in patients with locally advanced...
