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Cancer stem cells: an insight into the development of metastatic tumors and therapy resistance
The term “cancer stem cells” (CSCs) refers to cancer cells that exhibit traits parallel to normal stem cells, namely the potential to give rise to...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
BackgroundCancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, progression,...
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Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities
BackgroundTumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells...
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Detection and Isolation of Cancer Stem Cells
The discovery and isolation of the hematopoietic stem cell (HSC) from bone marrow grafts introduced the concept of a cell type capable of restoring...
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WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway
Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is compensated by generating new cells with the capacity for...
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Pituitary stem cells: past, present and future perspectives
Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary...
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Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
In the past decade, induced pluripotent stem cells (iPSCs) technology has significantly progressed in studying malignant solid tumors. This...
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Cancer cells as a new source of induced pluripotent stem cells
Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential applications in various medical research areas, from...
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DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway
DIS3L2 degrades different types of RNAs in an exosome-independent manner including mRNAs and several types of non-coding RNAs. DIS3L2-mediated...
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Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells
BackgroundGlioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival...
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Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression
BackgroundThe glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in...
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Paracrine Factors Released from Tonsil-Derived Mesenchymal Stem Cells Inhibit Proliferation of Hematological Cancer Cells Under Hyperthermia in Co-culture Model
Mesenchymal stem cells (MSCs) are promising biological therapeutic candidates in cancer treatment. As a source of MSCs, palatine tonsil tissue is one...
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The interaction of mast cells with membranes from lung cancer cells induces the release of extracellular vesicles with a unique miRNA signature
Mast cells (MCs) are immune cells that play roles in both normal and abnormal processes. They have been linked to tumor progression in several types...
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GFP Transfection Alters Protein Expression Patterns in Prostate Cancer Cells: A Proteomic Study
PurposeGreen Fluorescent Protein is widely used as a cellular marker tool, but its potential influence on cells has been questioned. Although the...
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Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment
BackgroundGlioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current...
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Colon Cancer Stem Cells
Colorectal cancer (CRC) is the third common cause of cancer-related deaths globally. It begins nearly as a benign polyp and slowly develops into a...
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Colon Cancer Stem Cells
Colorectal cancer (CRC) is the third common cause of cancer-related deaths globally. It begins nearly as a benign polyp and slowly develops into a...
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Linking EMT programmes to normal and neoplastic epithelial stem cells
Epithelial stem cells serve critical physiological functions in the generation, maintenance and repair of diverse tissues through their ability to...
