Search
Search Results
-
CaSSiDI: novel single-cell “Cluster Similarity Scoring and Distinction Index” reveals critical functions for PirB and context-dependent Cebpb repression
PirB is an inhibitory cell surface receptor particularly prominent on myeloid cells. PirB curtails the phenotypes of activated macrophages during...
-
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate...
-
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
BackgroundHyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of...
-
Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI
Growing opioid use among pregnant women is fueling a crisis of infants born with prenatal opioid exposure. A large body of research has been devoted...
-
Immunolocalization of zinc transporters and metallothioneins reveals links to microvascular morphology and functions
Zinc homeostasis is vital to immune and other organ system functions, yet over a quarter of the world’s population is zinc deficient. Abnormal zinc...
-
Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. Cortical neurons are born during embryonic development,...
-
Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases
Sestrin2 (SESN2), a highly conserved stress-responsive protein, can be triggered by various noxious stimuli, such as hypoxia, DNA damage, oxidative...
-
Neuromodulation of Motor Functions Using Noninvasive Cerebellar and Spinal Direct Current Stimulation
This review presents neurophysiological and behavioral data obtained in experimental and clinical studies in recent years based on noninvasive...
-
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) peptide on pancreatic...
-
Efficiency of Pexidartinib, an Inhibitor of Receptor Tyrosine Kinases, in Reducing Radiation-Induced Neuroinflammation and Improving Cognitive Functions
Colony-stimulating factor 1 receptor (CSF1R) possesses tyrosine kinase activity. Activation of CSF1R expressed on the surface of brain microglia...
-
Populational heterogeneity and partial migratory origin of the ventromedial hypothalamic nucleus: genoarchitectonic analysis in the mouse
The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern...
-
Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
BackgroundUnderstanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors to shed light on...
-
The Molecular and Biochemical Variations during Cancer Prognosis in Mouse Models
Cancer is a dreadful disease that causes morbidity and mortality; cancer is caused due to metabolic reprogramming and genetic variations....
-
MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia
Resistance to tyrosine kinase inhibitors (TKIs) remains a clinical challenge in Ph-positive variants of chronic myeloid leukemia. We provide...
-
Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
Proteomic profiling of brain cell types using isolation-based strategies pose limitations in resolving cellular phenotypes representative of their...
-
Antidepressant-like effects of cinnamamide derivative M2 via D2 receptors in the mouse medial prefrontal cortex
Major depressive disorder is a global mental illness associated with severe mortality and disability. The dopaminergic system is involved in both the...
-
Possible transfer of lncRNA H19-derived miRNA miR-675-3p to adjacent H19-non-expressing trophoblast cells in near-term mouse placenta
LncRNA H19 serves as a regulatory RNA in mouse placental development. However, there is little information available on the in situ expression of H19 ...
-
Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis
Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue. E-cadherin–catenin complexes mediate Ca 2+ -dependent trans- homodime...
-
Administration of metformin ameliorates endocrine abnormalities associated with mouse model of PCOS by increasing Cyp19a1 expression
A number of reproductive aged women often suffer from polycystic ovarian syndrome (PCOS). This study attempted to determine how metformin affects the...
-
Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer’s disease and cognition
Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors (CHRM1) in patients with schizophrenia which is significant...
