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Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM
LRRK2 is one of the most promising drug targets for Parkinson’s disease. Though type I kinase inhibitors of LRRK2 are under clinical trials,...
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A leucine-rich repeat-receptor-like kinase gene SbER2–1 from sorghum (Sorghum bicolor L.) confers drought tolerance in maize
BackgroundERECTA ( ER ) is a leucine-rich repeat-receptor-like kinase gene (LRR-RLK) encoding a protein isolated from Arabidopsis . Although the...
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The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the...
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Wheat powdery mildew resistance gene Pm13 encodes a mixed lineage kinase domain-like protein
Wheat powdery mildew is one of the most destructive diseases threatening global wheat production. The wild relatives of wheat constitute rich sources...
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Role of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE (SARK) in senescence regulation and developmental processes in Arabidopsis
In light of increasing environmental stress, understanding the biological roles and molecular mechanisms of the genes implicated in senescence...
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Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s disease
PurposeCardiac autonomic dysfunction manifests as reduced heart rate variability (HRV) in idiopathic Parkinson’s disease (PD), but no significant...
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Molecular dynamic investigation for Roco4 kinase inhibitor as treatment options for parkinsonism
ContextParkinson's disease is a neurodegenerative condition characterized by the degeneration of dopaminergic neurons, resulting in motor...
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Subtilase-mediated biogenesis of the expanded family of SERINE RICH ENDOGENOUS PEPTIDES
Plant signalling peptides are typically released from larger precursors by proteolytic cleavage to regulate plant growth, development and stress...
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Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Morphological rearrangement of the endoplasmic reticulum (ER) is critical for metazoan mitosis. Yet, how the ER is remodeled by the mitotic signaling...
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Conservation of Protein Kinase A Substrates in the Cnidarian Coral Spermatozoa Among Animals and Their Molecular Evolution
The coral Acropora spp., known for its reef-building abilities, is a simultaneous hermaphroditic broadcast spawning species. Acropora spp. release...
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Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide
Temozolomide (TMZ) insensitivity and resistance are major causes of treatment failure and poor prognosis for GBM patients. Here, we identify LRRC4 as...
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Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway
Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery...
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Mitogen-Activated Protein Kinase: A Potent Signaling Protein that Combats Biotic and Abiotic Stress in Plants
Serine kinases, also identified as mitogen-activated protein kinases (MAPKs), are involved in the transmission of cellular signals that carry out...
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Genome-wide association study of Senegalese sorghum seedlings responding to a Texas isolate of Colletotrichum sublineola
Colletotrichum sublineola is a destructive fungal pathogen that causes anthracnose in sorghum. Senegalese sorghum germplasm is currently being...
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The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled...
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Identification of the early leaf senescence gene ELS3 in bread wheat (Triticum aestivum L.)
Main conclusionCharacterization of the early leaf senescence mutant els3 and identification of its causal gene ELS3 , which encodes an LRR-RLK...
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Unusual metal ion cofactor requirement of Entamoeba histolytica choline and ethanolamine kinase isoforms
The de novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine in Entamoeba histolytica is largely dependent on the CDP-choline and...
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Targeting NLRP3 inflammasome for neurodegenerative disorders
Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer’s disease (AD). The nucleotide-binding domain...
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Phylogeny of the plant receptor-like kinase (RLK) gene family and expression analysis of wheat RLK genes in response to biotic and abiotic stresses
BackgroundThe receptor-like kinase (RLK) gene families in plants contains a large number of members. They are membrane proteins with an extracellular...
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Genome-wide characterization of the NBLRR gene family provides evolutionary and functional insights into blast resistance in pearl millet (Cenchrus americanus (L.) Morrone)
Main conclusionThe investigation is the first report on genome-wide identification and characterization of NBLRR genes in pearl millet. We have shown...
