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Low-frequency electrical stimulation of bilateral hind legs by belt electrodes is effective for preventing denervation-induced atrophies in multiple skeletal muscle groups in rats
Belt electrode skeletal muscle electrical stimulation (B-SES) can simultaneously contract multiple muscle groups. Although the beneficial effects of...
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Uridine Administration Promotes Normalization of Heart Mitochondrial Function in Dystrophin-Deficient Mice and Decreases Tissue Fibrosis
The work shows the effect of the metabolic modulator uridine on the functioning and ultrastructure of heart mitochondria in dystrophin-deficient mdx ...
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Diversity and complexity of cell death: a historical review
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an...
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ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors
BackgroundATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a...
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Switching cell fate by the actin–auxin oscillator in Taxus: cellular aspects of plant cell fermentation
Key messagePaclitaxel synthesis in Taxus cells correlates with a cell-fate switch that leads to vacuoles of a glossy appearance and vermiform...
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Involvement of histone methylation in the regulation of neuronal death
Neuronal death occurs in various physiological and pathological processes, and apoptosis, necrosis, and ferroptosis are three major forms of neuronal...
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Photosensitized Oxidation of Intracellular Targets: Understanding the Mechanisms to Improve the Efficiency of Photodynamic Therapy
The development of improved photosensitizers is a key aspect in the establishment of photodynamic therapy (PDT) as a reliable treatment modality. In...
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Nonspecific Permeability Pore (mPTP) in Plant Mitochondria and Its Role in Cell Death
AbstractCurrent concepts are reviewed concerning the structure, regulatory mechanisms, and the functional role of nonspecific permeability pore (also...
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Altered Energy Metabolism, Mitochondrial Dysfunction, and Redox Imbalance Influencing Reproductive Performance in Granulosa Cells and Oocyte During Aging
Female fertility decreases during aging. The development of effective therapeutic strategies to address the age-related decline in oocyte quality and...
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Commitment to a Dementia-Free Society
Your brain is always thinking of something. Even now your brain is thinking of something. Ten seconds later it is thinking of something and 20 s...
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The Neurotoxic Effect of β-Amyloid Is Accompanied by Changes in the Mitochondrial Dynamics and Autophagy in Neurons and Brain Endothelial Cells in the Experimental Model of Alzheimer’s Disease
A comparative assessment of the expression of the mitochondrial fission marker Drp1 and the autophagy marker LC3 in neurons and endothelial cells in...
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Ischemic Preconditioning of the Kidney
The phenomenon of ischemic preconditioning was discovered in 1986 in experiments with the heart, and then it was observed in almost all organs, the...
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The status and trends of mitochondrial dynamics research: A global bibliometric and visualized analysis
BackgroundMitochondria are remarkably dynamic organelles encapsulated by bilayer membranes. The dynamic properties of mitochondria are critical for...
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Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues
The chapter considers mechanisms by which cells regulate calcium and phosphate ion homeostasis with respect to the induction of extracellular...
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Crosstalk Between Abnormal Electrical Activity and Angiotensin II Cell Signaling in the Hyperglycemic Mammalian Heart
It has been well-accepted that an up-regulation of not only the systemic but also local cardiac renin angiotensin systemRenin angiotensin system...
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Biogenesis of Mitochondria in Multipotent Mesenchymal Stromal Cells in Patients with Acute Leukemia
In patients with acute leukemia, not only normal hematopoiesis, but also bone marrow stromal microenvironment is damaged. Multipotent mesenchymal...
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Metabolic dysfunction and the development of physical frailty: an aging war of attrition
The World Health Organization recently declared 2021–2030 the decade of healthy aging. Such emphasis on healthy aging requires an understanding of...
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The Science of Living Longer
Attaining immortality or finding the fountain of eternal youth have been recurring themes and a constant quest of mankind since time immemorial....
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Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to...
