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Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report
BackgroundThe concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is...
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The podocytes’ inflammatory responses in experimental GN are independent of canonical MYD88-dependent toll-like receptor signaling
Podocytes form the kidney filtration barrier and continuously adjust to external stimuli to preserve their integrity even in the presence of...
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Atypical anti-glomerular basement membrane disease with membranous hyperplasia: diagnostic challenges and treatment variability
This case report presents a detailed analysis of a 31-year-old male patient who presented with a complex array of clinical symptoms, including...
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An unusual case of nephrotic syndrome
BackgroundAlport syndrome is a genetically heterogenous disorder resulting from variants in genes coding for alpha-3/4/5 chains of Collagen IV, which...
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Medullary sponge kidney with IgA nephropathy: a case report and literature review
BackgroundMedullary sponge kidney (MSK)is rare in association with glomerulonephritis. We report a patient with medullary sponge kidney, and the...
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Nephrotic syndrome induced by aortic regurgitation with Takayasu arteritis: an autopsy case with long-term clinical follow-up
Takayasu arteritis is a rare, chronic, and large-vessel vasculitis involving the aorta and its branches in a complex autoimmune reaction. Takayasu...
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LAMB2 gene: broad clinical spectrum in Pierson syndrome
Pierson syndrome (PS) is a rare autosomal recessive disease, characterized by congenital nephrotic syndrome (CNS), and ocular and neurologic...
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Glycosphingolipid GM3 prevents albuminuria and podocytopathy induced by anti-nephrin antibody
Podocytopathy, which is characterized by injury to podocytes, frequently causes proteinuria or nephrotic syndrome. There is currently a paucity of...
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Polydatin nanoparticles attenuate oxidative stress and histopathological changes in streptozotocin model of diabetic nephropathy: targeting Nrf2/HO-1/NF-κβ signaling pathways
BackgroundOne of the most prevalent and serious side effects of diabetes mellitus is diabetic nephropathy, which is characterized by abnormalities in...
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Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a unique component of the ubiquitin–proteasome system (UPS), which has multiple activities in...
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Membranous nephropathy after multiple Hymenoptera stings: a case report
An association between Hymenoptera (bee and wasp) stings and nephrotic syndrome has been rarely reported. We report a case of nephrotic syndrome...
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Clinicopathological differences in focal segmental glomerulosclerosis depending on the accompanying pathophysiological conditions in renal allografts
Primary focal segmental glomerulosclerosis (FSGS) is thought to be caused by circulating factors leading to podocytopathy, whereas segmental...
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Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
BackgroundSteroid-resistant nephrotic syndrome (SRNS) is characterized by unrelieved proteinuria after an initial 4–8 weeks of glucocorticoid...
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A case of minimal change disease after the administration of anti receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal antibody: a case report
BackgroundMinimal change disease (MCD) is one of the causes of idiopathic nephrotic syndrome in adults. The pathogenesis of proteinuria in MCD has...
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Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway
PurposeThis study aims to investigate the mechanism underlying the beneficial effects of Huangqi decoction (HQD) on Diabetic kidney disease (DKD) in...
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Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp®, a supplement containing red yeast rice
Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have...
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Hidden genetics behind glomerular scars: an opportunity to understand the heterogeneity of focal segmental glomerulosclerosis?
Focal segmental glomerulosclerosis (FSGS) is a complex disease which describes different kinds of kidney defects, not exclusively linked with...
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Nicotinamide protects against diabetic kidney disease through regulation of Sirt1
PurposeTo investigate the effect of nicotinamide (Nam) on diabetic kidney disease (DKD) in mice and explore its mechanism.
MethodsThirty DBA/2 J...
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Electron Microscopy of Glomerular Involvement in Autoimmune Diseases Other Than SLE
This chapter will provide an overview of the clinical and pathological features of glomerular involvement in non-lupus autoimmune diseases, followed...