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Modulation of fluoroquinolone resistance by Lippia origanoides Kunth in Staphylococcus aureus
In this study, the ethanolic extract, and the dichloromethane fraction from L. origanoides were assessed for their antibacterial activity alone or in...
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Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells
HSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors (HSP90i) are characterized by limited clinical utility, primarily due...
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Acinetobacter baumannii Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors
Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic human pathogen, and the drastic dissemination of multidrug resistance in A....
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Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations
Understanding the precise mechanistic details of the possible binding and transport of antiseizure medications (ASMs) through the P-glycoprotein...
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Sequence-Specific Gene Silencing of acrA in the Multi-drug Efflux System AcrAB Induces Sensitivity in Drug-Resistant Klebsiella pneumoniae
Multi-drug efflux is one of the resistant determinants in Klebsiella pneumoniae that are encountered in a broad range of clinically relevant...
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Prediction model of human ABCC2/MRP2 efflux pump inhibitors: a QSAR study
AbstractThe overexpression of ABCC2/MRP2, an ATP-binding cassette transporter, contributes to multidrug resistance in cancer cells. In this study, a...
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The Role of Essential Oils in the Inhibition of Efflux Pumps and Reversion of Bacterial Resistance to Antimicrobials
Due to the deaths from infections caused by multidrug-resistant microorganisms worldwide, the World Health Organization considers antibiotic...
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Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors
FtsZ inhibitors represent a new drug class as no drugs using this mode of action (MOA) have been approved by regulators. 3-alkoxy substituted...
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Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps
The Staphylococcus aureus bacteria is a Gram-positive, immobile, non-spore bacterium, with catalase and positive coagulase, among other...
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Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of...
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Evaluation the effect of ZnO nanoparticle derived Bacillus subtilis on the expression of efflux pump genes (AdeB AdeRS) in Acinetobacter baumannii
PurposeGreen approach to the nanoparticles, including metal oxides due to inevitable disadvantages of physical or chemical synthesis routes is...
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Application and Optimization of Concentric Pipe Jet Pump Drainage Gas Production Technology in the South Area of Sulige Gas Field
Gas Wells in the south area of Sulige Gas field generally produce water and accumulated liquid. The main drainage gas recovery measures such as...
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Enhancement of the antibiotic activity by quercetin against Staphylococcus aureus efflux pumps
The objective of this work was to evaluate the inhibitory effect of quercetin on S. aureus Efflux Pumps. The MIC of Quercetin was evaluated through...
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Chemical composition and potentiating action of Norfloxacin mediated by the essential oil of Piper caldense C.D.C. against Staphylococcus aureus strains overexpressing efflux pump genes
Infectious diseases caused by multidrug-resistant microorganisms has increased in the last years. Piper species have been reported as a natural...
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Measuring Efflux and Permeability in Mycobacteria
Mycobacteria are intrinsically resistant to most antimicrobials, which is generally attributed to the impermeability of their cell wall that...
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Application of fed-batch strategy to fully eliminate the negative effect of lignocellulose-derived inhibitors in ABE fermentation
BackgroundInhibitors that are released from lignocellulose biomass during its treatment represent one of the major bottlenecks hindering its massive...
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Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
Upon antibiotic stress Gram-negative pathogens deploy resistance-nodulation-cell division-type tripartite efflux pumps. These include a H + /drug...
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Overcoming anticancer resistance by photodynamic therapy-related efflux pump deactivation and ultrasound-mediated improved drug delivery efficiency
One of the major obstacles to successful chemotherapy is multi-drug resistance (MDR). A multi-drug resistant cancerous cell abnormally overexpresses...
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PARP Inhibitors in Breast Cancer: a Short Communication
Purpose of ReviewIn the last decade, poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in the treatment of several cancers, such as...
