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Construction of microfluidic blood–brain barrier model assisted by 3D coculture on cellulose fiber
In this study, we fabricated a microfluidic device to mimic the human blood–brain barrier (BBB) in vitro, comprising a cellulose fiber membrane...
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Kinetic Detection of Apoptosis Events Via Caspase 3/7 Activation in a Tumor-Immune Microenvironment on a Chip
The development of advanced biological models like microphysiological systems, able to rebuild the complexity of the physiological and/or...
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Coaggregated E. faecalis with F. nucleatum regulated environmental stress responses and inflammatory effects
AbstractTo investigate the cell-cell interactions of intergeneric bacterial species, the study detected the survival of Enterococcus faecalis (Ef)...
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Design of stable and self-regulated microbial consortia for chemical synthesis
Microbial coculture engineering has emerged as a promising strategy for biomanufacturing. Stability and self-regulation pose a significant challenge...
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Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids
BackgroundWithin the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous...
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Fibroblasts and mouse breast cancer cells can form cellular aggregates in improved soft agar culture medium
We aimed to build cellular aggregates of TS/A and normal fibroblasts (LX-2) or CAFs (ME-iLX-2), verifying the value of this model in the screening of...
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Intravital Microscopy for Imaging and Live Cell Tracking of Alveolar Macrophages in Real Time
Classic in vitro coculture assays of pathogens with host cells have contributed significantly to our understanding of the intracellular lifestyle of...
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Generating an In Vitro Gut Model with Physiologically Relevant Biophysical Mucus Properties
IntroductionGastrointestinal (GI) in vitro models have received lasting attention as an effective tool to model drug and nutrient absorption, study...
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Microbiome analysis reveals the intestinal microbiota characteristics and potential impact of Procambarus clarkii
AbstractThe intestinal microbiota interacts with the host and plays an important role in the immune response, digestive physiology, and regulation of...
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Development of a thermophilic coculture for corn fiber conversion to ethanol
The fiber in corn kernels, currently unutilized in the corn to ethanol process, represents an opportunity for introduction of cellulose conversion...
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Functional and analytical recapitulation of osteoclast biology on demineralized bone paper
Osteoclasts are the primary target for osteoporosis drug development. Recent animal studies revealed the crucial roles of osteoblasts in regulating...
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Synthetic auxotrophs accelerate cell factory development through growth-coupled models
The engineering of microbial cell factories for the production of high-value chemicals from renewable resources presents several challenges,...
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Tumor-matched and unmatched cancer associated fibroblasts exhibit differential effect on proliferation and FMOD and MMP9 gene expression in head and neck squamous cell carcinoma cells when cocultured in spheroids
BackgroundCancer-associated fibroblasts (CAFs) are the major cellular component of the tumor microenvironment and are known to affect tumor growth...
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Chlorin e6-associated photodynamic therapy enhances abscopal antitumor effects via inhibition of PD-1/PD-L1 immune checkpoint
We hypothesized that photodynamic therapy (PDT) with Chlorin e6 (Ce6) enhances antitumor abscopal effects via inhibition of the programmed cell...
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Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Although many studies have compared tumor fibroblasts (T-Fbs) and nontumor fibroblasts (N-Fbs), less is understood about the stromal contribution of...
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Exploring a new mechanism between lactate and VSMC calcification: PARP1/POLG/UCP2 signaling pathway and imbalance of mitochondrial homeostasis
Lactate leads to the imbalance of mitochondria homeostasis, which then promotes vascular calcification. PARP1 can upregulate osteogenic genes and...
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Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for...
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Microbial Advancements in Dark Fermentative Biohydrogen Production: Applications and Innovations
Direct or indirect biophotolysis, photo-fermentation, and dark fermentation are all methods of biohydrogen production (BHP), with the latter being...
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Monitoring Angiotropic Extravascular Migratory Metastasis In Vitro
The mechanism of cancer cell migration from the primary tumor toward secondary sites is not fully understood. In addition to intravascular cellular...
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Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment
PurposeAdrenocortical carcinoma (ACC), a rare malignancy of the adrenocortex, is characterized by a crosstalk between the adipose microenvironment...
