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Protein–protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer–Rokitansky–Küster–Hauser syndrome
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype....
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Drug repurposing and prediction of multiple interaction types via graph embedding
BackgroundFinding drugs that can interact with a specific target to induce a desired therapeutic outcome is key deliverable in drug discovery for...
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Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition
BackgroundDNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting....
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Identification of hub genes involved in cisplatin resistance in head and neck cancer
BackgroundCisplatin resistance is one of the major contributors to the poor survival rate among head and neck cancer (HNC) patients. Focusing on the...
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The role of RNA modification in urological cancers: mechanisms and clinical potential
RNA modification is a post-transcriptional level of regulation that is widely distributed in all types of RNAs, including mRNA, tRNA, rRNA, miRNA,...
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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained...
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KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells
Breast cancer has become the most common type of cancers worldwide. Its high prevalence and malignant features are associated with various...
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Comparison of hormone-induced mRNA and protein biomarker expression changes in breast cancer cells
PurposeProtein biomarkers estrogen receptor (ER), progesterone receptor (PR), and marker of proliferation (Ki67) are routinely assessed by...
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Construction autophagy-related prognostic risk signature combined with clinicopathological validation analysis for survival prediction of kidney renal papillary cell carcinoma patients
BackgroundLittle data is available on prognostic biomarkers and effective treatment options for Kidney Renal Papillary Cell Carcinoma (KIRP)...
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Heat Shock Proteins and HSF1 in Ferroptosis
When cells are exposed to various stressors, such as heat, toxins, or oxidative stress, heat shock transcription factor 1 (HSF1) becomes activated...
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HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations
PurposeTreatment of advanced colorectal cancer (CRC) depends on the correct selection of personalized strategies. HAMLET (Human Alpha-lactalbumin...
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Potential Signature Therapeutic Biomarkers TOP2A, MAD2L1, and CDK1 in Colorectal Cancer: A Systems Biomedicine-Based Approach
Colorectal cancer is the third deadliest and fourth most diagnosed cancer. It is heterogeneously driven by varied mutations and mutagens, and thus,...
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Identification of SPRYD4 as a tumour suppressor predicts prognosis and correlates with immune infiltration in cholangiocarcinoma
Cholangiocarcinoma (CCA) is an aggressive solid tumour with a 5-year survival rate ranging from 7% to 20%. It is, therefore, urgent to identify novel...
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Construction and validation of a prognostic model based on autophagy-related genes for hepatocellular carcinoma in the Asian population
Background and objectiveHepatocellular carcinoma (HCC), which has a complex pathogenesis and poor prognosis, is one of the most common malignancies...
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High expression of HSP60 and survivin predicts poor prognosis for oral squamous cell carcinoma patients
BackgroundHSP60 is a heat shock proteins (HSPs) family member and help mitochondrial protein to fold correctly. Survivin is one of the inhibitors of...
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Therapeutic targeting of the TPX2/TTK network in colorectal cancer
BackgroundWhile the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC)...
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RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2
RNF6 is a RING finger protein with oncogenic potential. In this study, we established colon-specific RNF6 transgenic (tg) mice, and demonstrated that...
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Cytotoxicity and Gene Expression Studies of Curcumin and Piperine Loaded Nanoparticles on Breast Cancer Cells
AbstractThe aim of this study was to investigate the anticancer effects of curcumin and piperine loaded nanoparticles compared to docetaxel on the...
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Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow
Disturbed blood flow (d-flow) has been known to induce changes of the cells in the arterial wall, increasing the risk of atherosclerosis. However,...
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Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma (MCL) are incompletely understood. We characterize the...
