Search
Search Results
-
Exploring low-dose gamma radiation effects on monoterpene biosynthesis in Thymus vulgaris: insights into plant defense mechanisms
Thymus vulgaris , commonly known as thyme, is a plant renowned for producing monoterpenes. This study aimed to understand the effects of low-dose...
-
Oncology dose optimization paradigms: knowledge gained and extrapolated from approved oncology therapeutics
There has been increasing attention to dose optimization in the development of targeted oncology therapeutics. The current report has analyzed the...
-
Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer....
-
A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance
Despite tremendous progress in precision oncology, adaptive resistance mechanisms limit the long-term effectiveness of molecularly targeted agents....
-
UNet with ResNextify and IB modules for low-dose CT image denoising
In recent years, low-dose computed tomography (LDCT) scans have surpassed traditional CT scans in popularity as people grow more health conscious....
-
Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells
PurposeThymoquinone (TQ) and rosmarinic acid (RA) are two biologically active compounds found in plants and that possess remarkable anti-oxidant and...
-
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
Cells are inevitably challenged by low-level/endogenous stresses that do not arrest DNA replication. Here, in human primary cells, we discovered and...
-
Safety and immunogenicity following a homologous booster dose of CoronaVac in children and adolescents
Data on safety and immunity elicited by a third booster dose of inactivated COVID-19 vaccine in children and adolescents are scarce. Here we...
-
Metronomic chemotherapy plus anti-PD-1 in metastatic breast cancer: a Bayesian adaptive randomized phase 2 trial
It remains unclear whether metronomic chemotherapy is superior to conventional chemotherapy when combined with immune checkpoint blockade. Here we...
-
The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models
Background/aimsPrimary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The imbalance of Th17/Treg cells has been reported in PBC...
-
Generative AI in Medical Imaging and Its Application in Low Dose Computed Tomography (CT) Image Denoising
Deep learning techniques have made its way to the medical field. Medical images are essential tools for visualizing internal body structures up to...
-
Rapid evolution of an adaptive taste polymorphism disrupts courtship behavior
The evolution of adaptive behavior often requires changes in sensory systems. However, rapid adaptive changes in sensory traits can adversely affect...
-
The why and how of adaptive immune responses in ischemic cardiovascular disease
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide. Most therapeutic approaches target traditional risk...
-
A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis
In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2...
-
Radiation dose rate effects: what is new and what is needed?
Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate....
-
Review of Statistical Treatment for Oncology Dose-Escalation Trial with Prolonged Evaluation Window or Fast Enrollment
In this chapter, we start with the review on three classes of methodologies for oncology dose-escalation trial design: the 3+3, the statistical...
-
Bacteroides uniformis CECT 7771 requires adaptive immunity to improve glucose tolerance but not to prevent body weight gain in diet-induced obese mice
BackgroundThe metabolic disturbances of obesity can be mitigated by strategies modulating the gut microbiota. In this study, we sought to identify...
-
Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study
Aims/hypothesisLow-dose IL-2 (ld-IL2) selectively activates and expands regulatory T cells (Tregs) and thus has the potential to skew the...
-
Adaptive scans allow 3D-targeted laser dissection to probe the mechanics of cell sheets
The mechanical actuation of cells by active forces from the cytoskeleton drives tissue morphogenesis. To understand these forces, multicellular laser...
-
Hormetic Effects of Low Dose Gamma Irradiation on Antioxidant Defense System and Thymol Biosynthesis in Thyme Plants
AbstractThis study investigated the impact of different doses (0, 1, 3, and 5 Gy) of gamma radiation on antioxidant mechanisms and thymol...
