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Application of Viruses for Gene Therapy and Vaccine Development
Although viruses have been demonstrated to cause a serious threat to our health, further confirmed by the current coronavirus virus pandemic,...
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A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release
BackgroundSeveral studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both...
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Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been...
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Construction of a replication-competent retroviral vector for expression of the VSV-G envelope glycoprotein for cancer gene therapy
Gibbon ape leukemia virus (GALV) can infect a wide variety of cells but fails to infect most cells derived from laboratory mice. Transduction of...
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Novel viruses belonging to the family Circoviridae identified in wild American wigeon samples
Members of the family Circoviridae are known to infect several avian species, with the ability to cause severe disease outcomes in some species....
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Do the Biological Roles of Endogenous and Lysogenous Viruses Represent Faustian Bargains?
Genetic transference between a host species and its viruses results in development of a collective genome which has fluidity and influences...
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Infectivity and genetic recombination of yellow mosaic viruses associated with blackgram (Vigna mungo L. Hepper) in South India
The pulse crops widely cultivated in South India for their protein rich grains are negatively affected by whitefly-transmitted begomoviruses (genus Begomovirus...
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Vector-Mediated Cancer Gene Therapy Reduces Toxicity and Inhibition of Lung Carcinoma Growth in Nude Mice
Replication-competent oncolytic adenovirus (TOA2) gene therapy is a recently introduced anti-tumor treatment regimen with superior results. The...
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Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus
African swine fever (ASF) is an infectious disease caused by ASF virus (ASFV), which is characterized by high infectivity, rapid onset of disease,...
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Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses
Evasion of growth suppression is among the prominent hallmarks of cancer. Phosphatase and tensin homolog (PTEN) and p53 tumor-suppressive pathways...
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Viruses and the Evolution of Viral Vectors
Since the first documented, widespread use of vaccines in the eighteenth century, vaccines have become a common health preventative for humans and...
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Evaluation of two artificial infection methods of live ticks as tools for studying interactions between tick-borne viruses and their tick vectors
Up to 170 tick-borne viruses (TBVs) have been identified to date. However, there is a paucity of information regarding TBVs and their interaction...
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Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
Influenza viruses cause a significant number of infections and deaths annually. In addition to seasonal infections, the risk of an influenza virus...
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Vaccines for Emerging Viruses—A Comprehensive Update
Over the past decade several notable viruses have suddenly emerged from obscurity to become serious public health problems and global threats,...
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Lentiviral Transduction of Mammary Epithelial Cells
Lentiviral vectors are the workhorses of modern cell biology. They can infect a wide variety of cells including non-dividing cells and stem cells....
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Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and potential future spillovers of...
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Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology
Endogenous retroviruses (ERVs) are retroviral sequences present in the host genomes. Although most ERVs are inactivated, some are produced as...
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Reverse Genetics for Influenza A and B Viruses Driven by Swine Polymerase I Promoter
Influenza viruses are considered prominent pathogens of humans and animals that are extensively investigated because of public health importance....
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Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples
In low-resource settings, resilience to infectious disease outbreaks can be hindered by limited access to diagnostic tests. Here we report the...
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Structural insights into RNA polymerases of negative-sense RNA viruses
RNA viruses include many important human and animal pathogens, such as the influenza viruses, respiratory syncytial virus, Ebola virus, measles virus...
