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A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein (FMRP), an RNA-binding protein that can regulate the...
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The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain
Studies of associative learning have commonly focused on how rewarding outcomes are predicted by either sensory stimuli or animals’ actions. However,...
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Self-organization of human dorsal-ventral forebrain structures by light induced SHH
Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body’s axes during embryogenesis. While...
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Cholinergic basal forebrain and hippocampal structure influence visuospatial memory in Parkinson’s disease
Visuospatial impairment in Parkinson’s disease (PD) heralds the onset of a progressive dementia syndrome and might be associated with cholinergic...
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice
BackgroundNeuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE)....
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Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids
It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may...
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Insulin and Brain Gangliosides Prevent Metabolic Disorders Caused by Activation of Free Radical Reactions after Two-Vessel Ischemia–Reperfusion Injury to the Rat Forebrain
AbstractThe ability of insulin and gangliosides, administered separately or jointly, to increase the viability of cultured brain cortical neurons...
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Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4+/− mice
ObjectiveSulfation is an essential physiological process that regulates the function of a wide array of molecules involved in brain development. We...
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Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder
We utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of Autism Spectrum Disorder (ASD)...
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Deep brain stimulation of the “medial forebrain bundle”: sustained efficacy of antidepressant effect over years
Deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle (MFB) has emerged as a quite efficacious therapy for...
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Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats
BackgroundImbalanced synaptic transmission appears to be an early driver in Alzheimer’s disease (AD) leading to brain network alterations. Early...
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Dynamic encoding of phonetic categories in zebra finch auditory forebrain
Vocal communication requires the formation of acoustic categories to enable invariant representations of sounds despite superficial variations....
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GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can...
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Brain metabolic changes and clinical response to superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression
Deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle is an efficacious therapy for treatment-resistant depression,...
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Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
The growing recognition of a dichotomous role of astrocytes in neurodegenerative processes has heightened the need for unraveling distinct astrocytic...
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Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus
Neurons in the paraventricular nucleus of the thalamus (PVT) respond to emotionally salient events and project densely to subcortical regions known...
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Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation
Malfunction of the ventral subiculum (vSub), the main subregion controlling the output connections from the hippocampus, is associated with major...
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Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia
A potential pathophysiological mechanism of cognitive difficulties in schizophrenia is a dysregulated cholinergic system. Particularly, the...
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Activation patterns in male and female forebrain circuitries during food consumption under novelty
The influence of novelty on feeding behavior is significant and can override both homeostatic and hedonic drives due to the uncertainty of potential...
