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Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway
AbstractPlatelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative...
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Lipocalin 2 regulates mitochondrial phospholipidome remodeling, dynamics, and function in brown adipose tissue in male mice
Mitochondrial function is vital for energy metabolism in thermogenic adipocytes. Impaired mitochondrial bioenergetics in brown adipocytes are linked...
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A case of choroidal neovascularization as a first manifestaion of systemic lupus erythematosus
BackgroundTo report a rare occurrence of pigment epitheliopathy associated with choroidal neovasculization as a first manifestation of systemic lupus...
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Lung adenocarcinoma and squamous cell carcinoma difficult for immunohistochemical diagnosis can be distinguished by lipid profile
In patients with unresectable non-small cell lung cancer, histological diagnosis is frequently based on small biopsy specimens unsuitable for...
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Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis
Cigarette smoke is the primary cause of Chronic Obstructive Pulmonary Disorder (COPD). Cigarette smoke extract (CSE)-induced oxidative damage of the...
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Curvature sensing lipid dynamics in a mitochondrial inner membrane model
Membrane curvature is essential for many cellular structures and processes, and factors such as leaflet asymmetry, lipid composition, and proteins...
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HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy
Radiotherapy resistance is a major obstacle to nasopharyngeal carcinoma (NPC) therapy and contributes to tumour recurrence and metastasis. Lipid...
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Antibacterial activity and mechanisms of D-3263 against Staphylococcus aureus
Multi-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin...
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Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma
There is a complete lack of highly sensitive and specific biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis, limiting...
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Membrane curvature induces cardiolipin sorting
Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific...
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Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data
BackgroundBarth syndrome (BTHS) is a rare genetic disease that is characterized by cardiomyopathy, skeletal myopathy, neutropenia, and growth...
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Prevalence, clinical significance, and persistence of autoantibodies in COVID-19
BackgroundInterest in complications and sequelae following Coronavirus disease 2019 (COVID-19) is increasing. Several articles have reported...
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Early Stage of Structural Changes and Molecular Dynamics of Cytochrome C in an Aqueous Solution Caused by the Addition of Methanol
AbstractMolecular dynamics simulations of horse heart cytochrome C were performed in an aqueous solution and in a 50 : 50 water–methanol mixture....
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Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion
Translocation of preproteins across the Escherichia coli inner membrane requires anionic lipids by virtue of their negative head-group charge either in...
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IgA vasculitis with transient glomerular hematuria, diarrhea, and pericarditis following COVID-19 mRNA vaccination in a young patient with possible pre-existing ulcerative colitis
Exacerbations or de novo autoimmune/autoinflammatory disease have been reported after COVID-19 vaccination. A young male presented with cutaneous IgA...
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Phospholipid scramblase 3: a latent mediator connecting mitochondria and heavy metal apoptosis
Lead and mercury are the ubiquitous heavy metals triggering toxicity and initiating apoptosis in cells. Though the toxic effects of heavy metals on...
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Laparoscopic Cerclage in a Case of Unicornuate Uterus with Cervical Insufficiency and Previous Failed Mc Donald Cerclage with a Successful Outcome: A Case Report
In this report, we describe a 28-year-old woman, with unicornuate uterus and multiple mid-trimester losses, with two failed Mc Donald’s cerclage. She...
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Human HSP70-escort protein 1 (hHep1) interacts with negatively charged lipid bilayers and cell membranes
Human Hsp70-escort protein 1 (hHep1) is a cochaperone that assists in the function and stability of mitochondrial HSPA9. Similar to HSPA9, hHep1 is...
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Correlation between neuropsychiatric systemic lupus erythematosus and immunological markers: a real-world retrospective study
ObjectivesThis study aimed to investigate disparities in clinical profiles and autoantibody patterns between patients with and without...
