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Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya
BackgroundAlthough it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by...
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Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy
BackgroundPlasmodium falciparum and Plasmodium vivax are endemic in Vanuatu and the Solomon Islands. While both countries have introduced...
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Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia
BackgroundIntermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases adverse effects of malaria...
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Declining efficacy of artesunate plus sulphadoxine-pyrimethamine in northeastern India
BackgroundAnti-malarial drug resistance in Plasmodium falciparum in India has historically travelled from northeast India along the Myanmar border....
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Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
BackgroundSulphadoxine-pyrimethamine (SP), an antifolate, was replaced by artemether-lumefantrine as the first-line malaria drug treatment in Kenya...
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Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study
BackgroundIntermittent Preventive Treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) is widely used for the control of malaria in...
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Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia
BackgroundThe sulphadoxine/pyrimethamine (SDX/PYR) combination had been chosen to treat uncomplicated falciparum malaria in Malaysia for more than...
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A clinical and molecular study of artesunate + sulphadoxine-pyrimethamine in three districts of central and eastern India
BackgroundArtesunate + sulphadoxine-pyrimethamine (AS + SP) is recommended throughout India as the first-line treatment for uncomplicated falciparum...
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Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
BackgroundArtesunate plus sulphadoxine-pyrimethamine (AS+SP) is now first-line treatment for Plasmodium falciparum infection in several south Asian...
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High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin
BackgroundDespite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy...
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Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal
BackgroundIn sub-Saharan Africa, malaria is the leading cause of morbidity and mortality especially in children. In Senegal, seasonal malaria...
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Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
BackgroundIn Plasmodium , the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same...
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Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya
BackgroundResistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate...
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Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China
BackgroundThe mutations in Plasmodium falciparum chloroquine resistance transporter ( pfcrt ), multidrug resistance 1 ( pfmdr1 ), dihydrofolate...
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High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children
BackgroundDrug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase ( dhfr ) and dihydropteroate...
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Molecular markers in Plasmodium falciparum linked to resistance to anti-malarial drugs in samples imported from Africa over an eight-year period (2002-2010): impact of the introduction of artemisinin combination therapy
BackgroundDrug resistance is a major problem to control Plasmodium falciparum infection in endemic countries. During last decade, African countries...
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Molecular epidemiology of Plasmodium vivax anti-folate resistance in India
BackgroundSulphadoxine and pyrimethamine are anti-folate drugs that show synergistic anti-malarial effect. Point mutations in dihydrofolate reductase ...
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Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine–pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
Several studies have shown the efficacy of the intermittent preventive treatment (IPT) using sulfadoxine–pyrimethamine (SP) coupled with the expanded...
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Detection of high levels of mutations involved in anti-malarial drug resistance in Plasmodium falciparum and Plasmodium vivax at a rural hospital in southern Ethiopia
BackgroundIn Ethiopia, malaria is caused by Plasmodium falciparum and Plasmodium vivax , and anti-malarial drug resistance is the most pressing...
