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FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice
Alzheimer’s disease (AD) is the most common dementia. It is known that women with one ApoE4 allele display greater risk and earlier onset of AD...
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Unraveling Estrogen and PCSK9’s Roles in Lipid Metabolism Disorders among Ovariectomized Mice
We explore the interaction between estrogen and PCSK9 and their collective impact on lipid metabolism, especially concerning the regulation of...
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Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Bone and mineral metabolism homeostasis accounts for the maintenance of normal skeletal remodeling. However, with aging and changes in hormone...
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Oncological outcomes of conversion therapy in gastric cancer patients with peritoneal metastasis: a large-scale retrospective cohort study
BackgroundData on the long-term oncological outcomes of patients who undergo conversion surgery (CS) in gastric cancer (GC) patients with peritoneal...
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Ortho-silicic Acid Inhibits RANKL-Induced Osteoclastogenesis and Reverses Ovariectomy-Induced Bone Loss In Vivo
Numerous experiments in vitro and in vivo have shown that an appropriate increase intake of silicon can facilitate the synthesis of collagen and its...
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Daytime administration of melatonin has better protective effects on bone loss in ovariectomized rats
ObjectiveTo explore the difference in the protective effects of intraperitoneal injection of exogenous melatonin of daytime or nighttime on bone loss...
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Role of Estrogen in Attenuating Apoptosis and Cardiac Dysfunction in Female Heart Failure
Cardiovascular diseases including heart failure are the major cause of morbidity and mortality in both males and females of all ages and ethnicities....
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Changes in Inflammatory Response, Redox Status and Na+, K+-ATPase Activity in Primary Astrocyte Cultures from Female Wistar Rats Subject to Ovariectomy
Astrocytes are dynamic glial cells that maintain brain homeostasis, particularly metabolic functions, inflammatory response, and antioxidant defense....
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Calcium-Deficit Diet Improves Iron Content in Ovariectomized Rats
In women, menopause is associated with disorders related to calcium and iron content, which may increase the risk of osteoporosis. This study aimed...
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Elderly Women Have a Higher Survival Rate of Grafted Donor Fat than Do Young Women Under the Influence of Low Estrogen Conditions
BackgroundFat grafting is widely used in breast reconstruction and aesthetic plastic surgery. However, the success rate and effects of fat grafting,...
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Spectral Analysis of Spongy Bone Tissue after Ovariectomy and the Efficacy of Recovery Using Allogeneic Hydroxyapatite
AbstractDuring the work, experimental studies of spongy bone tissue of animals after ovariectomy and evaluation of its regeneration by allogeneic...
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Buckwheat tartary regulates the Gsk-3β/β-catenin pathway to prevent neurobehavioral impairments in a rat model of surgical menopause
Menopause is a natural aging process characterized by decreased levels of sex hormones in females. Deprivation of estrogen following menopause...
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Description of Ovariectomy Protocol in Mice
Estrogen and ovarian function decline are relevant characteristics of menopause period. Numerous physiological, metabolic and immunological...
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Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle’s disease from SFRP4 mutations
Mutations in SFRP4 cause Pyle’s bone disease with wide metaphyses and increased skeletal fragility. The WNT signaling pathway plays important roles...
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Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function
It is well-established that women are disproportionately affected by Alzheimer’s disease. The mechanisms underlying this sex-specific disparity are...
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Long Term Ovariectomy-Induced Osteoporosis is Associated with High Stearoyl-CoA Desaturase Indexes in Rat Femur
Osteoporosis is characterized by a bone loss associated to an increased bone marrow adiposity; however, it is still unclear what kind of lipids are...
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Removal of the ovaries suppresses ethanol drinking and promotes aversion-resistance in C57BL/6J female mice
RationaleFemale rodents consume more ethanol (EtOH) than males and exhibit greater aversion-resistant drinking in some paradigms. Ovarian hormones...
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Daily supplement of sesame oil prevents postmenopausal osteoporosis via maintaining serum estrogen and aromatase levels in rats
Estrogen deficiency is one of the main causes of postmenopausal osteoporosis in elderly women. Hormone replacement therapy has been employed to...
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Evaluation of the effect of vitamin D3 on mandibular condyles in an ovariectomized mouse model: a micro-CT study
BackgroundThis study aimed to investigate the effect of ovariectomy and vitamin D3 on bone microstructure; this effect was examined in three regions...
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Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats
BackgroundOsteoporosis (OP) is a systemic skeletal disease marked by bone mass reduction and bone tissue destruction. Hormone replacement therapy is...
