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Structure and function of mammalian aldehyde oxidases
Mammalian aldehyde oxidases (AOXs; EC1.2.3.1) are a group of conserved proteins belonging to the family of molybdo-flavoenzymes along with the...
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A phylogenomic and molecular marker based proposal for the division of the genus Borrelia into two genera: the emended genus Borrelia containing only the members of the relapsing fever Borrelia, and the genus Borreliella gen. nov. containing the members of the Lyme disease Borrelia (Borrelia burgdorferi sensu lato complex)
The genus Borrelia contains two groups of organisms: the causative agents of Lyme disease and their relatives and the causative agents of relapsing...
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Early gene expression in Pseudomonas fluorescens exposed to a polymetallic solution
The molecular response of Pseudomonas fluorescens cells exposed to a mixture of heavy metals remains largely unknown. Here, we studied the temporal...
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Phytoplasma Genomes: Evolution Through Mutually Complementary Mechanisms, Gene Loss and Horizontal Acquisition
Phytoplasmas are cell wall-less bacteria that inhabit phloem sieve cells of infected plants and are transmitted by phloem-feeding insect vectors....
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Investigating Host–Pathogen Behavior and Their Interaction Using Genome-Scale Metabolic Network Models
Genome Scale Metabolic Modeling methods represent one way to compute whole cell function starting from the genome sequence of an organism and...
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Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism
Pyridine compounds, including nicotinic acid and nicotinamide, are key metabolites of both the salvage pathway for NAD and the biosynthesis of...
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Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues
Current studies in plants suggest that the content of the coenzyme NAD is variable and potentially important in determining cell fate. In cases that...
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Dissimilatory Sulfate- and Sulfur-Reducing Prokaryotes
This chapter provides an overview of prokaryotes that reduce oxygenated sulfate or elemental sulfur in their energy metabolism. Sulfate-reducing...
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A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T
BackgroundNatrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions...
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Structure-based functional inference of hypothetical proteins from Mycoplasma hyopneumoniae
Enzootic pneumonia caused by Mycoplasma hyopneumoniae is a major constraint to efficient pork production throughout the world. This pathogen has a...
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Molecular signatures for the phylum Synergistetes and some of its subclades
Species belonging to the phylum Synergistetes are poorly characterized. Though the known species display Gram-negative characteristics and the...
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The Phylogenomic Roots of Modern Biochemistry: Origins of Proteins, Cofactors and Protein Biosynthesis
The complexity of modern biochemistry developed gradually on early Earth as new molecules and structures populated the emerging cellular systems....
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Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis
Mycobacteria synthesize intracellular methylglucose lipopolysaccharides (MGLP) proposed to regulate fatty acid synthesis. Although their structures...
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Genome-wide essential gene identification in Streptococcus sanguinis
A clear perception of gene essentiality in bacterial pathogens is pivotal for identifying drug targets to combat emergence of new pathogens and...
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Nicotinamide Coenzyme Synthesis: A Case of Ribonucleotide Emergence or a Byproduct of the RNA World?
Coenzymes likely represent the oldest metabolic fossils within a cell, as suggested by their presence and essentiality in all kingdoms of life and...
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Nampt and Its Potential Role in Inflammation and Type 2 Diabetes
Nicotinamide phosphoribosyltransferase (Nampt Nampt...
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Whole genome wide expression profiles of Vitis amurensisgrape responding to downy mildew by using Solexa sequencing technology
BackgroundDowny mildew (DM), caused by pathogen Plasmopara viticola (PV) is the single most damaging disease of grapes ( Vitis L.) worldwide....
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Two genome sequences of the same bacterial strain, Gluconacetobacter diazotrophicus PAl 5, suggest a new standard in genome sequence submission
Gluconacetobacter diazotrophicus PAl 5 is of agricultural significance due to its ability to provide fixed nitrogen to plants. Consequently, its...
