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Correlation of ChREBP Gene Methylation with Pathological Characteristics of Type 2 Diabetes Mellitus
The objective of this study is to investigate the expression of the carbohydrate response element binding protein (ChREBP) gene in type 2 diabetes...
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Methylation of Regulatory Regions of DNA Repair Genes in Carotid Atherosclerosis
AbstractThe status of DNA methylation in the human genome changes during the pathogenesis of common diseases and acts as a predictor of life...
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Nonlinear DNA methylation trajectories in aging male mice
Although DNA methylation data yields highly accurate age predictors, little is known about the dynamics of this quintessential epigenomic biomarker...
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Targeted Nanopore Resequencing and Methylation Analysis of LINE-1 Retrotransposons
Retrotransposition of LINE-1 (L1) elements represents a major source of insertional polymorphisms in mammals, and their mutagenic activity is...
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Alterations of DNA methylation profile in peripheral blood of children with simple obesity
PurposeTo investigate the association between DNA methylation and childhood simple obesity.
MethodsGenome-wide analysis of DNA methylation was...
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Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins
BackgroundElevated fasting plasma glucose (FPG) levels can increase morbidity and mortality even when it is below the diagnostic threshold of type 2...
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Clinical significance of RNA methylation in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput...
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Repeat DNA methylation is modulated by adherens junction signaling
Through its involvement in gene transcription and heterochromatin formation, DNA methylation regulates how cells interact with their environment....
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Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption
Osteoporosis has a profound influence on public health. First-line bisphosphonates often cause osteonecrosis of the jaw meanwhile inhibiting...
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Curcumin can improve spinal cord injury by inhibiting DNA methylation
Spinal cord injury (SCI) is a serious central nervous system disease. Traumatic SCI often causes persistent neurological deficits below the injury...
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Recent advance of microbial mercury methylation in the environment
AbstractMethylmercury formation is mainly driven by microbial-mediated process. The mechanism of microbial mercury methylation has become a crucial...
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Methylation in cornea and corneal diseases: a systematic review
Corneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive,...
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Fresh and frozen cardiac tissue are comparable in DNA methylation array β-values, but formalin-fixed, paraffin-embedded tissue may overestimate DNA methylation levels
Untreated fresh cardiac tissue is the optimal tissue material for investigating DNA methylation patterns of cardiac biology and diseases. However,...
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A supervised learning method for classifying methylation disorders
BackgroundDNA methylation is one of the most stable and well-characterized epigenetic alterations in humans. Accordingly, it has already found...
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DNA Methylation is Involved in Sex Determination in Spinach
DNA methylation plays a critical role in the modulation of gene expression. The role of DNA methylation in sex determination was investigated in...
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The underlying mechanisms of DNA methylation in high salt memory in hypertensive vascular disease
This study demonstrates the effect and DNA methylation-related mechanisms of a high-salt diet and salt memory-induced hypertension and vasculopathy....
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Nucleic acid and protein methylation modification in renal diseases
Although great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that...
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Evaluating Reliability of DNA Methylation Measurement
DNA methylation is a widely studied epigenetic phenomenon. Alterations in methylation patterns influence human phenotypes and risk of disease. The...
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A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma
To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests, we set out to find HCC-specific methylation markers and...
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DNA Methylation in Prokaryotes
The genomes of bacteria, archaea, and phage contain small amounts of C5-methylcytosine, N4-methylcytosine, and N6-methyladenine. Base methylation...