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Metabolic Pathways in Pediatric Cancers
Cancer in children have a high burden and affects the children’s lives as well as their families for almost the rest of their lives. Moreover,...
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Obesity, Myokines, and Metabolic Health
Skeletal muscle is a major determinant of energy expenditure and glucose disposal. Muscle fibers express and secrete several peptides, defined as...
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Obesity, Myokines, and Metabolic Health
Skeletal muscle is a major determinant of energy expenditure and glucose disposal. Muscle fibers express and secrete several peptides, defined as...
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Siderophore-synthesizing NRPS reprogram lipid metabolic profiles for phenotype and function changes of Arthrobotrys oligospora
The objective of this paper is to explore the function of the AOL-s00215g415 ( Aog415 ) gene, which encodes for the synthesis of siderophore in the...
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
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Metabolic Disorders Affecting the Kidney
Inherited diseases of metabolism may have kidney involvement either inaugural or as a long-term chronic complication with heterogeneous mechanisms....
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Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy
IntroductionAs one of the major components of the tumor microenvironment, tumor-associated macrophages (TAMs) possess profound inhibitory activity...
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Metabolic and Inflammatory Profiles Across Infertile PCOS Phenotypes: Implications for Clinical Practice
BackgroundPolycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting women of reproductive age, coupled with an array of...
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Cancer Drug Resistance and Metabolic Reprogramming
There is a complex and strong association between metabolic reprogramming and the phenomenon of drug resistance in cancer. Cancer cell metabolic...
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Sex-Gender-Based Differences in Metabolic Diseases
Sexual dimorphism creates different biological and cellular activities and selective regulation mechanisms in males and females, thus generating...
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LC–qTOF-MS analysis of fish immune organs reveals the distribution of amino acids in response to metabolic adaptation of the survival phenotype in grouper against Vibrio infection
Epinephelus fuscoguttatus is economically crucial to various Southeast Asia countries where they are reared in fish farms to meet the demand for...
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Metabolic Enzymes: Polymorphisms and Species Differences
Before elimination from the body, foreign compounds to which humans are exposed undergo metabolic conversion mediated by phase I and phase II...
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Metabolic Engineering for Improving Vegetable Oils
Synthetic biology’s application to metabolic engineering allows the production of biomolecules of interest for applications for the chemical,...
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Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context, tumour metabolic heterogeneity arises and develops in...
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Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis....
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Metabolic Reprogramming As a Prostate Cancer Hallmark
Arising from a disruption of regular biological circuits and control mechanisms, cancer exhibits a remarkable inter- and intra-type heterogeneity, an...
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Metabolic and immunological phenotype of rare lipomatoses: Dercum’s disease and Roch-Leri mesosomatic lipomatosis
ContextDercum’s disease (DD) and Roch-Leri mesosomatic lipomatosis (LMS) are rare and poorly characterized diseases. The clinical presentation...
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Lipid metabolic vulnerabilities of multiple myeloma
Multiple myeloma (MM) is the second most common hematological malignancy worldwide, characterized by abnormal proliferation of malignant plasma cells...
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Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types
Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function. Yet, the metabolic reconfiguration of RA...
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Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
BackgroundAdipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease...
