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Targeting the undruggable: menin inhibitors ante portas
Acute myeloid leukaemias harbouring a rearrangement of the mixed lineage leukaemia gene (MLL) are aggressive haematopoietic malignancies that relapse...
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Non-genetic determinants of malignant clonal fitness at single-cell resolution
All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic...
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Cell competition in development, homeostasis and cancer
Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue architecture and function....
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In the Pipeline: Emerging Therapy for Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is an aggressive, heterogenous, and age-related haematological malignancy with dismal prognosis. Conventional therapy...
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Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia
BackgroundPaediatric acute myeloid leukaemia (AML) is characterized by poor outcomes in patients with relapsed/refractory disease, despite the...
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Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway
PurposeIs it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments...
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Multiple Reddish Swellings on the Gum: Leukemia
Leukemia, the most common malignancy of the hemopoietic system, is a disease featuring an uncontrolled proliferation of myeloid or lymphoid cells....
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Mature B cell acute lymphoblastic leukaemia with KMT2A-MLLT3 transcripts in children: three case reports and literature reviews
BackgroundMature B cell acute lymphoblastic leukaemia (BAL) is characterised by French–American–British (FAB)-L3 morphology and the presence of...
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The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation
BackgroundChimeric antigen receptor (CAR) T-cells have revolutionized the treatment of CD19- and B-cell maturation antigen-positive haematological...
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Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme
CAR T-cell therapy has transformed relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukaemia (B-ALL) management and outcomes, but...
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The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia
The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically...
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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HLA in Transplantation
This chapter is about kidney and bone marrow transplantation, a therapy that is routinely used in our hospitals to correct a failure of different...
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Rapid manufacturing of non-activated potent CAR T cells
Chimaeric antigen receptor (CAR) T cells can generate durable clinical responses in B-cell haematologic malignancies. The manufacturing of these T...
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Relapse after CAR-T cell therapy in B-cell malignancies: challenges and future approaches
Chimeric antigen receptor-T (CAR-T) cell therapy, as a novel cellular immunotherapy, has dramatically reshaped the landscape of cancer treatment,...
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Advancing CAR T cell therapy through the use of multidimensional omics data
Despite the notable success of chimeric antigen receptor (CAR) T cell therapies in the treatment of certain haematological malignancies, challenges...
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Selective haematological cancer eradication with preserved haematopoiesis
Haematopoietic stem cell (HSC) transplantation (HSCT) is the only curative treatment for a broad range of haematological malignancies, but the...
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Leukaemia: a model metastatic disease
In contrast to solid cancers, which often require genetic modifications and complex cellular reprogramming for effective metastatic dissemination,...
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A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells
The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack...
