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A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who...
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A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of...
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Why is polymyalgia rheumatica a disease of older adults? Explanations through etiology and pathogenesis: a narrative review
Polymyalgia rheumatica is one of the most common inflammatory rheumatic conditions in older adults. The disease is characterized by pain and...
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The Senescence-Associated Secretory Phenotype: Induction, Regulation, Function and Therapeutic Interventions to Counteract the Negative Effects
Aging is characterized by a status of chronic low-grade systemic inflammation called “inflammaging”, that represents a leading cause of diseases...
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Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging
BackgroundInflammaging is a persistent, low−grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system....
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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and...
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Immunology: Features of Immunesenescence
Advancing age is accompanied by remodelling of the immune system and impaired ability to mount a robust immune response (immunesenescence) and...
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Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice
Peritoneal immune cell function is a reliable indicator of aging and longevity in mice and inflammaging is associated with a shorter lifespan....
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Inflammaging
Inflammaging is a theory of aging based on the evidence that the evolutionary unpredicted persistent/increasing exposure to a variety of external and...
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On frailty and accelerated aging during SARS-Cov-2: senescence
The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially...
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Aging and chronic inflammation: highlights from a multidisciplinary workshop
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and...
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Immunosenescence of T cells: a key player in rheumatoid arthritis
IntroductionThe incidence of rheumatoid arthritis (RA) and its complications are expected to increase with age. Remarkably, RA patients were...
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Klonale Hämatopoese – Ursachen und klinische Implikationen
Clonal hematopoiesis of indeterminate potential (CHIP) refers to hematopoiesis from stem cells with mutations in leukemia-associated driver genes....
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Aging and homeostasis of the hypodermis in the age-related deterioration of skin function
Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the endocrine organ for the maintenance of skin homeostasis...
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Immunosenescence and Alzheimer’s Disease
Alzheimer’s disease (AD) is the most frequent cause of dementia due to neurodegeneration. It is stated that the most important risk factor for the...
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Sepsis in elderly patients: the role of neutrophils in pathophysiology and therapy
Sepsis is among the most important causes of mortality, particularly within the elderly population. Sepsis prevalence is on the rise due to different...
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“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
BackgroundThe loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of which is...
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sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
BackgroundInflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is...
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Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice
Accumulation of alpha-synuclein (α-syn) is central to the pathogenesis of Parkinson’s disease (PD). Previous studies suggest that α-syn pathology may...
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Klonale Hämatopoese – Ursachen und klinische Implikationen
Clonal hematopoiesis of indeterminate potential (CHIP) refers to hematopoiesis from stem cells with mutations in leukemia-associated driver genes....
