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Chromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
The common dolphin ( Delphinus delphis ) is widely distributed worldwide and well adapted to various habitats. Animal genomes store clues about their...
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Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases
The polyglutamine (polyQ) diseases are a group of nine fatal, adult-onset neurodegenerative disorders characterized by the misfolding and aggregation...
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This...
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Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation
The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy....
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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
BackgroundMutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown,...
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Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila
N 6 -methyladenosine (m 6 A), the most prevalent internal modification on eukaryotic mRNA, plays an essential role in various stress responses. The brain...
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Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei into complex droplets (anisosomes) comprised of...
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Control of SOX2 protein stability and tumorigenic activity by E3 ligase CHIP in esophageal cancer cells
SOX2 is highly expressed and controls tumor initiation and cancer stem cell function in various squamous cell carcinomas including esophageal...
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Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality
BackgroundIn vitro production of bovine embryos is a well-established technology, but the in vitro culture (IVC) system still warrants improvements,...
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RNA-seq analysis and reconstruction of gene networks involved in response to salinity stress in quinoa (cv. Titicaca)
To better understand the mechanisms involved in salinity stress, the adaptability of quinoa cv. Titicaca—a halophytic plant—was investigated at the...
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The combination of hypoxia and high temperature affects heat shock, anaerobic metabolism, and pentose phosphate pathway key components responses in the white shrimp (Litopenaeus vannamei)
Due to global warming, world water bodies have higher temperatures and lower oxygen concentrations that affect aquatic species including the white...
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Transcriptomic analysis of the black tiger shrimp (Penaeus monodon) reveals insights into immune development in their early life stages
With the rapid growth in the global demand, the shrimp industry needs integrated approaches for sustainable production. A high-quality shrimp larva...
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Differential expression of heat shock protein genes in Rhipicephalus sanguineus (Acari: Ixodidae) exposed to temperature and humidity variations
The brown dog tick ( Rhipicephalus sanguineus ), a well-recognized parasite that is an important vector of many pathogens, widely distributed in the...
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Silicon triggers the signalling molecules and stress-associated genes for alleviating the adverse effect of terminal heat stress in wheat with improved grain quality
Terminal heat stress severely affects the growth of wheat crop causing drastic reduction in the yield and nutritional quality of the grains. Various...
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Description of strongly heat-inducible heat shock protein 70 transcripts from Baikal endemic amphipods
Heat shock proteins/cognates 70 are chaperones essential for proper protein folding. This protein family comprises inducible members (Hsp70s) with...
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Differential Transcriptional Regulation of Drought Stress Revealed by Comparative RNA-seq Analysis of Contrasting indica Rice from North East India
Indica rice varieties especially from North East India show a broad variation in drought tolerance due to the rich biodiversity of the region. In...
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Transcriptome sequencing of the endangered land snail Karaftohelix adamsi from the Island Ulleung: De novo assembly, annotation, valuation of fitness genes and SSR markers
BackgroundThe Bradybaenidae snail Karaftohelix adamsi is endemic to Korea, with the species tracked from Island Ulleung in North Gyeongsang Province...
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Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy
The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing...
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Transcriptome Profiling in the Marine Red Alga Neopyropia yezoensis Under Light/Dark Cycle
Many organisms are subjected to a daily cycle of light and darkness, which significantly influences metabolic and physiological processes. In the...
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The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells
BackgroundHeat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is the most common internal RNA...
