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Gonadal transcriptomes reveal sex-biased expression genes associated with sex determination and differentiation in red-tail catfish (Hemibagrus wyckioides)
BackgroundRed-tail catfish ( Hemibagrus wyckioides ) is an important commercially farmed catfish in southern China. Males of red-tail catfish grow...
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SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β
Silent mating type information regulation 2 homolog 1 (SIRT1) is a class III histone deacetylase (HDAC) that is NAD + dependent and essential for...
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Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells
The functions and molecular mechanisms of long noncoding RNA (lncRNA) in reproduction have been widely studied at present. However, lncRNA regulating...
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Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells
BackgroundEstetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently...
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Integrated bioinformatics analysis for identifying key genes and pathways in female and male patients with dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a common cause of heart failure, and males are more likely to suffer from DCM than females. This research aimed at...
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RUNX1T1, a potential prognostic marker in breast cancer, is co-ordinately expressed with ERα, and regulated by estrogen receptor signalling in breast cancer cells
BackgroundRUNX1T1 is extensively studied in the context of AML1-RUNX1T1 fusion protein in acute myeloid leukemia. Little is known about the function...
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Identification of miR-192 target genes in porcine endometrial epithelial cells based on miRNA pull-down
IntroductionMicroRNAs (miRNAs)—a class of small endogenous non-coding RNAs—are widely involved in post-transcriptional gene regulation of numerous...
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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer
Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk...
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Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis
BackgroundThe issue of male fertility is becoming increasingly common due to genetic differences inherited over generations. Gene expression and...
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KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells
Breast cancer has become the most common type of cancers worldwide. Its high prevalence and malignant features are associated with various...
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Identification of key genes and miRNAs related to polycystic ovary syndrome by comprehensive analysis of microarray
BackgroundWe aimed to explore mechanisms of development and progression of polycystic ovary syndrome (PCOS).
MethodsThe microRNA expression...
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DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and...
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Germline mutations of breast cancer susceptibility genes through expanded genetic analysis in unselected Colombian patients
BackgroundIn Colombia and worldwide, breast cancer (BC) is the most frequently diagnosed neoplasia and the leading cause of death from cancer among...
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A pan-cancer analysis of anti-proliferative protein family genes for therapeutic targets in cancer
The recently discovered APRO (anti-proliferative protein) family encodes a group of trans-membrane glycoproteins and includes 6 members: TOB1, TOB2,...
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Signaling Pathways and Genes Associated with Hexavalent Chromium-Induced Hepatotoxicity
Exposure to hexavalent chromium [Cr(VI)] causes human and animal hepatotoxicity. However, it is unclear how Cr(VI) induces hepatotoxicity, nor is it...
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Bioinformatics analysis based on high-throughput sequencing data to identify hub genes related to different clinical types of COVID-19
This article aims to explore hub genes related to different clinical types of cases with COVID-19 and predict the therapeutic drugs related to severe...
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Bioinformatically deciphering immune cell infiltration and signature genes in pelvic organ prolapse
Introduction and hypothesisThe study is aimed at bioinformatically deciphering immune cell infiltration, signature genes, and their correlations in...
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Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer
Mutations in the estrogen receptor (ESR1) gene are common in ER-positive breast cancer patients who progress on endocrine therapies. Most mutations...
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Estrogen-dependent activation of NCOA3 couples with p300 and NF-κB to mediate antiapoptotic genes in ER-positive breast cancer cells
Circumvention of apoptosis by the elevation of antiapoptotic proteins is an important cause of carcinogenesis. The induction of antiapoptotic genes,...
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Identifying the genes involved in the egg-carrying ovigerous hair development of the female blue crab Callinectes sapidus: transcriptomic and genomic expression analyses
BackgroundCrustacean female sex hormone (CFSH) controls gradually develo** adult female-specific morphological features essential for mating and...
