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Clinical benefits of introducing real-time multiplex PCR for cerebrospinal fluid as routine diagnostic at a tertiary care pediatric center
BackgroundSepsis-like illness with suspected meningitis or encephalitis is a common reason for using empiric antimicrobial therapy in infants and...
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Chromosomal integration of HHV-6A during non-productive viral infection
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human...
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Viren mit doppelsträngigem DNA-Genom
Es sind viele Viren mit einem doppelsträngigen DNA-Genom bekannt, die Wirbeltiere infizieren. Die Menschen und Säugetiere infizierenden Viren werden...
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Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation
In this retrospective analysis using the Transplant Registry Unified Management Program, we identified 145 patients with human herpesvirus (HHV)-6...
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HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q
Primary effusion lymphomas (PEL) are associated with human herpesvirus-8 (HHV-8) and usually occur in immunocompromised individuals. However, there...
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Betaherpesvirus Complications and Management During Hematopoietic Stem Cell Transplantation
Two of the four betaherpesviruses, Cytomegalovirus (CMV) and human herpesvirus 6B (HHV-6B), play an important role in opportunistic infections in...
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Applications of Digital PCR in Clinical Microbiology
Several potential advantages have emerged in recent years for the use of digital PCR (dPCR) instead of real-time quantitative PCR (qPCR) in clinical...
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Using Droplet Digital PCR to Detect Coinfection of Human Herpesviruses 6A and 6B (HHV-6A and HHV-6B) in Clinical Samples
Droplet digital™ polymerase chain reaction (ddPCR™) is a unique digital PCR technique that allows for absolute quantification of nucleic acid...
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Human placenta has no microbiome but can contain potential pathogens
We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of infants who are small for gestational age were associated...
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Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals
The roseoloviruses, human herpesvirus (HHV)-6A, HHV-6B, and HHV-7, can cause severe encephalitis or encephalopathy. In immunocompetent children,...
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Viral Infections
Cutaneous viral infections comprise a heterogeneous group of diseases, with different degrees of severity, ranging from self-limited course to...
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Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia
Background:Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in...
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Human Herpesvirus-6, -7, and -8 After Solid Organ Transplantation
HHV-6 is a beta herpes virus that establishes latency after primary infection with most infections occurring in the childhood. Active HHV-6 infection...
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