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The cell cycle, autophagy, and cell wall integrity pathway jointly governed by MoSwe1 in Magnaporthe oryzae
The cell cycle is pivotal to cellular differentiation in plant pathogenic fungi. Cell wall integrity (CWI) signaling plays an essential role in...
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Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability
The deubiquitinase OTUB1, implicated as a potential oncogene in various tumors, lacks clarity in its regulatory mechanism in tumor progression. Our...
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Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle
BackgroundCancer radiation treatments have seen substantial advancements, yet the biomolecular mechanisms underlying cancer cell radioresistance...
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Intrinsic Resistance to Osimertinib in EGFR Mutated NSCLC Cell Lines Induced by Alteration in Cell-Cycle Regulators
BackgroundCell-cycle regulators are mutated in approximately 40% of all cancer types and have already been linked to worse outcomes in non-small cell...
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Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
The unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and...
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Regulatory miRNAs, circRNAs and lncRNAs in cell cycle progression of breast cancer
Breast cancer is a complex and heterogeneous disease that poses a significant public health concern worldwide, and it remains a major challenge...
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways
Cancer growth is a molecular mechanism initiated by genetic and epigenetic modifications that are involved in cell proliferation, differentiation,...
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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis
ObjectiveEndometrial carcinoma (EC) is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates. This...
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miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling
Osteosarcoma (OS) is a common bone malignancy and is diagnosed frequently in children and young adults. According to previous RNA sequencing,...
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SHR and SCR coordinate root patterning and growth early in the cell cycle
Precise control of cell division is essential for proper patterning and growth during the development of multicellular organisms. Coordination of...
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Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative...
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Whole-Mount Immunofluorescence Staining to Visualize Cell Cycle Progression in Mouse Oocyte Meiosis
Whole-mount immunofluorescence allows direct visualization of the cellular architecture within cells. Here, we apply this technique to mouse oocytes...
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CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
ObjectiveThis study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its...
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Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects
Identifying effective therapeutic treatment strategies is a major challenge to improving outcomes for patients with breast cancer. To gain a...
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Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression
Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mortality rate. Modern...
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DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity
BackgroundDisorder of cell cycle represents as a major driver of hepatocarcinogenesis and constitutes an attractive therapeutic target. However,...
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Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less...
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Life Cycle Assessment and Life Cycle Costing of a Unitized Regenerative Fuel Cell Stack: A Preliminary Study
The unitized regenerative fuel cell (URFC) with a polymeric electrolyte membrane (PEM) is an emerging energy storage system that could play an...
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Cell cycle specific, differentially tagged ribosomal proteins to measure phase specific transcriptomes from asynchronously cycling cells
Asynchronously cycling cells pose a challenge to the accurate characterization of phase-specific gene expression. Current strategies, including...
