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The Assessment of Cytotoxicity, Apoptosis Inducing Activity and Molecular Docking of a new Ciprofloxacin Derivative in Human Leukemic Cells
The fluoroquinolone class of antibiotics includes derivatives of the drug ciprofloxacin. These substances have recently been advocated for the...
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Map** the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining
BackgroundExposure to chemical mixtures inherent in air pollution, has been shown to be associated with the risk of breast and lung cancers. However,...
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Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation
BackgroundAlthough chondrosarcoma is the second most common primary malignant bone tumor, treatment options are limited due to its extensive...
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A novel tumor suppressor encoded by a 1p36.3 lncRNA functions as a phosphoinositide-binding protein repressing AKT phosphorylation/activation and promoting autophagy
Peptides/small proteins, encoded by noncanonical open reading frames (ORF) of previously claimed non-coding RNAs, have recently been recognized...
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Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells
BackgroundMultiple myeloma (MM) cells gain protection against drugs through interaction with bone marrow stromal cells (BMSCs). This form of...
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From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
MYB transcription factors are encoded by a large family of highly conserved genes from plants to vertebrates. There are three members of the MYB gene...
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Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients
BackgroundThe persistent the inflammatory condition in multiple sclerosis (MS) may due to the aberrant regulation of the elimination of the...
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Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells
Intervertebral disc (IVD) disease (IDD) is a complex, multifactorial disease. While various aspects of IDD progression have been reported, the...
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Bcl-2 dependent modulation of Hippo pathway in cancer cells
IntroductionBcl-2 and Bcl-xL are the most studied anti-apoptotic members of Bcl-2 family proteins. We previously characterized both of them, not only...
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Hypoxia in Drug Resistance and Radioresistance
Tumors mostly experience hypoxia or hypoxic stress as they progress, especially for tumor cells that are located far from the functional blood...
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SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs
Perturbations of the circadian clock are linked to multiple diseases, including cancers. Pharmacological activation of REV-ERB nuclear receptors, the...
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Tubulin Complexity in Cancer and Metastasis
Tubulin plays a fundamental role in cellular function and as the subject for microtubule-active agents in the treatment of ovarian cancer....
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Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis
Toxoplasma gondii is a worldwide parasite that can infect almost all kinds of mammals and cause fatal toxoplasmosis in immunocompromised patients....
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Trophinin-associated protein expression correlates with shorter survival of patients with glioma: a study based on multiple data fusion analysis
BackgroundTrophinin-associated protein ( TROAP ) mediates embryonic transfer, regulates microtubules, and is associated with the biological behavior...
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Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis
BackgroundOral squamous cell carcinoma (OSCC) is a malignant cancer, the survival rate of patients is disappointing. Therefore, it is necessary to...
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YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells
Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the...
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Fe3O4 magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN
BackgroundRadiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe 3 O 4 magnetic nanoparticles...
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Identification of key autophagy-related genes and pathways in spinal cord injury
Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous...
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Drug repurposing and prediction of multiple interaction types via graph embedding
BackgroundFinding drugs that can interact with a specific target to induce a desired therapeutic outcome is key deliverable in drug discovery for...
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Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
Breast cancer is the most frequently diagnosed cancer among women worldwide. Despite the initial clinical response obtained with the widely used...
