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Racial/Ethnic Disparities in Use of Angiotensin II Receptor Type 2/4 Stimulatory Vs. Inhibitory Antihypertensive Among Hypertensive Adults in the USA
ObjectivesStudies showed angiotensin II type 2 receptor/angiotensin II type 4 receptor (AT2R/AT4R) stimulatory antihypertensive was associated with a...
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Physician adherence and patient-reported outcomes in heart failure with reduced ejection fraction in the era of angiotensin receptor-neprilysin inhibitor therapy
This Korean nationwide, multicenter, noninterventional, prospective cohort study aimed to analyze physician adherence to guideline-recommended...
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Renin-Angiotensin System and Cancer: From Laboratory to Clinics
Renin-Angiotensin System (RAS) is a vital system regulating blood pressure and maintaining sodium homeostasis in the human body. It consists of...
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Renin Angiotensin System Inhibitors in Heart Failure with Reduced Ejection Fraction: Clinical Evidence and Considerations for Use
The renin angiotensin systemRenin angiotensin system (RAS) plays an important role in the regulation of body fluids and blood pressure. Therapy with...
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Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Coronary Syndrome: Implications for Platelet Reactivity?
BackgroundIn patients with acute coronary syndrome (ACS), angiotensin-converting enzyme (ACE) inhibitors are preferred over angiotensin receptor...
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Renin Angiotensin System Activity in Different Cancers: Mechanistic Insight and Preclinical Studies
The Renin Angiotensin System (RAS) is maintain arterial blood pressure as well as fluid and electrolyte balance in human body. In recent there...
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Preventing Progression of Chronic Kidney Disease: Renin–Angiotensin–Aldosterone System Blockade Beyond Blood Pressure
There is clear evidence for the pathogenic role of the renin–angiotensin–aldosterone system (RAAS) in the development and progression of CKD....
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Use of Angiotensin II Receptor Blockers, Angiotensin I-Converting Enzyme Polymorphism and Associations with Memory Performance in Older People
AbstractWe explored the relationships between the use of Angiotensin II receptor blockers (ARBs), Angiotensin I-converting enzyme (ACE) genetic...
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Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Insulin resistance is a major contributor to the pathogenesis of several human diseases, including type 2 diabetes, hypertension, and hyperlipidemia....
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Renin-angiotensin system inhibitor use and risk of Parkinson’s disease: a meta-analysis
BackgroundHypertension is a recognized risk factor for Parkinson’s disease (PD). The renin-angiotensin system (RAS) inhibitors are widely used to...
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Renin-Angiotensin-Aldosterone System Role in Organ Fibrosis
The normal healing process secondary to injury, disease or toxins is a mandatory process to human life. The healing process begins with hemostasis,...
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Implications of Renin-Angiotensin System in Health and Disease
The renin-angiotensin system (RAS) is one of major neuro-endocrine entity which is intimately involved in regulating the cellular functions and...
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Practical Recommendations for the Use of Angiotensin Receptor-Neprilysin Inhibitors (ARNI) in Heart Failure: Insights from Indian Cardiologists
Heart failure is a significant public health concern characterized by notable rates of morbidity and mortality. Despite the presence of...
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Diuretic and renal effects of angiotensin receptor-neprilysin inhibitor in patients hospitalized for acute heart failure
In patients hospitalized for acute decompensation of heart failure (HF), the impact of angiotensin receptor-neprilysin inhibitor (ARNI) on diuresis...
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The (pro)renin receptor as a pharmacological target in cardiorenal diseases
The (pro)renin receptor ((P)RR) is not only a member of the renin-angiotensin system (RAS) but also exerts several RAS-independent functions due to...
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Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians
Renin angiotensin system (RAS) alters various mechanisms related to muscle wasting. The RAS system consists of classical and non-classical pathways,...
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Clinical outcomes of renin angiotensin system inhibitor-based dual antihypertensive regimens in chronic kidney disease: a network meta-analysis
This study comprehensively investigated clinical outcomes associated with renin angiotensin system inhibitor-based dual antihypertensive regimens in...
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Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARBs) may be safe for COVID-19 patients
BackgroundTo investigate the effects of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blockers (ARBs) administration to...
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Comparing angiotensin receptor–neprilysin inhibitors with sodium–glucose cotransporter 2 inhibitors for heart failure with diabetes mellitus
Background and aimsClinical comparisons of angiotensin receptor–neprilysin inhibitors (ARNI) and sodium–glucose cotransporter 2 inhibitors (SGLT2i)...
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Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease
The role of autoimmunity in neurodegeneration has been increasingly suggested. The renin-angiotensin system (RAS) autoantibodies play a major role in...
