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Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast
BackgroundThe human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the...
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Radiation Dose Optimization: The Role of Artificial Intelligence
Artificial intelligence (AI) is transforming the world we live in, including medical imaging. One of the most exciting fields of research is the...
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Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics
Choroideremia is an X-linked, blinding retinal degeneration with progressive loss of photoreceptors, retinal pigment epithelial (RPE) cells, and...
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Dose Finding for Drug Combinations
We present early phase cancer clinical trial designs for drug combinations focusing on continuous dose levels. For phase I trials, the goal is to...
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Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph through afferent lymphatic vessels and from LNs into...
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Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma
BackgroundOsteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of...
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Immune Networks in the Context of Low Dose Ionizing Radiation
Irradiated tissues engage the immune system on many levels. The general assumption is that the initial damage alerts immune cells through universal...
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Adaptive liquid interfaces induce neuronal differentiation of mesenchymal stem cells through lipid raft assembly
Stem cells and their microenvironment interact cooperatively to dictate their fates. Biomaterials are dynamically remodeled by stem cells, and stem...
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Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome...
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Machine learning for adaptive deep brain stimulation in Parkinson’s disease: closing the loop
Parkinson’s disease (PD) is the second most common neurodegenerative disease bearing a severe social and economic impact. So far, there is no known...
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Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project
BackgroundAdaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further...
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Maternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder
Autism spectrum disorder (ASD) are neurodevelopmental conditions characterised by deficits in social communication and interaction and repetitive...
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Evolutionary based drug synergy prediction using adaptive Lévy based neural network structure
As cancer cases are looming large worldwide, the applications of data science and machine learning in these fields possess a greater scope especially...
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Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice
Adult neurogenesis generates new functional neurons from adult neural stem cells in various regions, including the subventricular zone (SVZ) of the...
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Effect of simultaneous exposure to inhalational anesthetics and radiation on the adaptive response in operating room personnel
Some operating room personnel, such as orthopedic surgeons, are exposed simultaneously to inhalational anesthetics (IAs) and radiation that both can...
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Improved ACOM pattern matching in 4D-STEM through adaptive sub-pixel peak detection and image reconstruction
The technique known as 4D-STEM has recently emerged as a powerful tool for the local characterization of crystalline structures in materials, such as...
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Practical guidance for planning resources required to support publicly-funded adaptive clinical trials
Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent...
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PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression
Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint...
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Exploring low-dose gamma radiation effects on monoterpene biosynthesis in Thymus vulgaris: insights into plant defense mechanisms
Thymus vulgaris , commonly known as thyme, is a plant renowned for producing monoterpenes. This study aimed to understand the effects of low-dose...
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Spatial structure impacts adaptive therapy by sha** intra-tumoral competition
BackgroundAdaptive therapy aims to tackle cancer drug resistance by leveraging resource competition between drug-sensitive and resistant cells. Here,...
