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Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease
Retinal ganglion cells (RGCs) are a heterogeneous population of neurons, comprised of numerous subtypes that work synchronously to transmit visual...
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Non-visual Opsins and Novel Photo-Detectors in the Vertebrate Inner Retina Mediate Light Responses Within the Blue Spectrum Region
In recent decades, a number of novel non-visual opsin photopigments belonging to the family of G protein- coupled receptors, likely involved in a...
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Towards intelligent illumination systems: from the basics of light science to its application
The development and design of lighting systems is closely linked to the physiology of the human visual system. Whereas with the first generation of...
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Quantum Biology of Circadian Rhythms
The 2017 Noble Prize in physiology or medicine was awarded to three scientists for their discoveries of molecular mechanisms that control circadian...
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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how...
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Effects of calibrated blue–yellow changes in light on the human circadian clock
Evening exposure to short-wavelength light can affect the circadian clock, sleep and alertness. Intrinsically photosensitive retinal ganglion cells...
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Molecular Genetic Mechanisms of Circadian Rhythm Regulation and Their Role in Psychopathology
AbstractCircadian rhythms are cyclic oscillations in the intensity of biological processes associated with the change of day and night, to which many...
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Pupillary response to chromatic light stimuli as a possible biomarker at the early stage of glaucoma: a review
Glaucoma is a multifactorial neurodegenerative disease of the optic nerve currently considered a severe health problem because of its high...
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Towards the Development and Validation of a Smartphone-Based Pupillometer for Neuro-Ophthalmological Diseases Screening
Pupillometry allows a quantitative measurement of PLR and has been mainly used to assess patient’s consciousness and vision function. The analysis of...
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Central retina plays a decisive role in the suppression of pupillary escape
PurposeTo explore the pupil redilation during persistent light exposure (pupillary escape phenomenon) at the macula and periphery with monochromatic...
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The association between pupillary responses and axial length in children differs as a function of season
The association between pupillary responses to repeated stimuli and adult refractive error has been previously demonstrated. This study evaluated...
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Influence of white-light-emitting diodes on primary visual cortex layer 5 pyramidal neurons (V1L5PNs) and remodeling by blue-light-blocking lenses
Studies have explored the consequences of excessive exposure to white-light-emitting diodes (LEDs) in the retina. Hence, we aimed to assess the...
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The structure–function relationship between multifocal pupil perimetry and retinal nerve fibre layer in glaucoma
BackgroundMultifocal pupillographic objective perimetry (mfPOP) is a novel method for assessing functional change in diseases like glaucoma. Previous...
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Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease?
Two multidimensional problems of recent times — Alzheimer’s disease and light pollution — seem to be more interrelated than previously expected. A...
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The Peculiarities of Circadian Rhythms and Their Implications on Parkinson’s Disease
Unsettling epidemiological data suggest Parkinson’s disease as the second most common neurodegenerative disorder worldwide. The worries persist as...
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Disruptions of Circadian Rhythms and Sleep/Wake Cycles in Neurologic Disorders
Throughout evolution, the temporal solar cycles of our rotating planet were internalized via circadian rhythms. These ~24-h internal rhythms drive...