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ZINC40099027 promotes monolayer circular defect closure by a novel pathway involving cytosolic activation of focal adhesion kinase and downstream paxillin and ERK1/2
ZINC40099027 (ZN27) is a specific focal adhesion kinase (FAK) activator that promotes murine mucosal wound closure after ischemic or NSAID-induced...
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Targeting of focal adhesion kinase enhances the immunogenic cell death of PEGylated liposome doxorubicin to optimize therapeutic responses of immune checkpoint blockade
BackgroundsImmune checkpoint blockade (ICB) is widely considered to exert long-term treatment benefits by activating antitumor immunity. However,...
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AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)
Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics,...
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Analysis of Actin and Focal Adhesion Organisation in U2OS Cells on Polymer Nanostructures
BackgroundIn this work, we explore how U2OS cells are affected by arrays of polymer nanopillars fabricated on flat glass surfaces. We focus on...
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Focal Adhesion Isolation Assay Using ECM-Coated Magnetic Beads
Focal adhesions are force sensitive structures that dynamically alter their composition, protein-protein interactions, and signaling in response to...
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Ihog proteins contribute to integrin-mediated focal adhesions
Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved,...
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Computational Design of Peptides with Improved Recognition of the Focal Adhesion Kinase FAT Domain
We describe a two-stage computational protein design (CPD) methodology for the design of peptides binding to the FAT domain of the protein focal...
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Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling
Hearing loss is the most common human sensory deficit. Hearing relies on stereocilia, inserted into the cuticular plate of hair cells (HCs), where...
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The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility
Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis,...
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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma
Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response...
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Focal adhesion kinase splicing and protein activation in papillary thyroid carcinoma progression
Papillary thyroid carcinoma (PTC), a common endocrine malignancy, presents a challenge from a prognostic standpoint. Molecular alterations underlying...
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The Combined Influence of Viscoelastic and Adhesive Cues on Fibroblast Spreading and Focal Adhesion Organization
IntroductionTissue fibrosis is characterized by progressive extracellular matrix (ECM) stiffening and loss of viscoelasticity that ultimately impairs...
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CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation,...
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Criticality in Cell Adhesion
In this chapter we apply the Ising model to describe the statics and kinetics of cell adhesion. We illuminate the many-body effects underlying the...
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Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects
BackgroundHepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) is one of the most...
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Local pH map** in the cell adhesion nano-interfaces on a pH-responsive fluorescence-dye-immobilized substrate
Cell-substrate adhesion nano-interfaces can, in principle, exhibit a spatial distribution of local pH values under the influence of the weakly acidic...
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The suppression of cell motility through the reduction of FAK activity and expression of cell adhesion proteins by hAMSCs secretome in MDA-MB-231 breast cancer cells
Breast cancer is a leading cause of death in women worldwide. Cancer therapy based on stem cells is considered as a novel and promising platform. In...
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Pitavastatin stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion
BackgroundExcessive angiogenesis of the retina is a key component of irreversible causes of blindness in many ocular diseases. Pitavastatin is a...
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In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells
To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring...
