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DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling
BackgroundThe DUSP4 gene plays an important role in the carcinogenesis of colorectal cancer (CRC). However, the underlying mechanism of...
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Effect of Dioscorea extract on Bax and Bcl-2 gene expression in MCF-7 and HFF cell lines
BackgroundIn cancer cells, the balance between proliferation and apoptosis is disturbed. There is a direct relationship between gene expression and...
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Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial...
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Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma
The BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-based apoptosis in models of neurodegeneration, including glaucomatous...
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Phillygenin Inhibits TGF-β1-induced Hepatic Stellate Cell Activation and Inflammation: Regulation of the Bax/Bcl-2 and Wnt/β-catenin Pathways
Hepatic fibrosis (HF), a precursor to cirrhosis and hepatocellular carcinoma, is caused by abnormal proliferation of connective tissue and excessive...
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Bacillus subtilis supernatant improves the efficacy of radiation therapy in rat intestinal epithelial cells by upregulation of bax and caspase-3 genes
BackgroundColorectal Cancer (CC) is among the most prevalent cancers in elderly persons. Radiotherapy is usually prescribed as CC develops, however,...
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The antitumor effect of oncolytic respiratory syncytial virus via the tumor necrosis factor-alpha induction and ROS-bax-mediated mechanisms
BackgroundCervical cancer represents one of the most prevalent cancers among women worldwide, particularly in low- and middle-income nations....
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer...
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Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
BackgroundOrgan toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an...
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Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs
BH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-survival proteins of...
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Royal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-κB/caspase-3/caspase-6/Bax and Erk signaling pathways in rats
This study is aimed at determining whether royal jelly (RJ) which has a powerful antioxidant property prevents fluoride-induced brain tissue damage...
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Combined laser-activated SVF and PRP remodeled spinal sclerosis via activation of Olig-2, MBP, and neurotrophic factors and inhibition of BAX and GFAP
A single injection of platelet-rich plasma (PRP) or stromal vascular fraction (SVF) in treating neurological ailments suggests promise; however,...
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Nickel oxide nanoparticles synthesized by Rose hip extract exert cytotoxicity against the HT-29 colon cancer cell line through the caspase-3/caspase-9/Bax pathway
In this study, the extract of Rose hip was used for the first time to synthesize nickel oxide nanoparticles (NiO NPs). The NiO NPs synthesized were...
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Knockout of BAX and BAK1 Genes and Overexpression of BCL2, BECN1 Genes Increase Lifespan and the Maximum Density of a CHO-S Cell Culture
Two genome editions have resulted in the CHO cell line 4BGD with homozygous knockouts of the BAK1 , BAX , DHFR and GLUL genes, and overexpression of...
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Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak
Apoptosis acts in defense against microbial infection, and many infectious agents have developed strategies to inhibit host cell apoptosis. The human...
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Cardiac remodeling, apoptosis-related process (Bax, Bcl-2), and their ratio (Bax/Bcl-2) in cardiomyocytes of diabetic rats after combined exercise training and taurine supplementation
Different modalities of exercise improve cardiac function in diabetes. This study evaluated the effects of Taurine supplementation plus endurance and...
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Advantages of Quantitative Analysis of Depth-Dependent Fluorescence Quenching: Case Study of BAX
Dynamic disorder of the lipid bilayer presents a challenge for establishing structure–function relationships in membrane proteins, especially to...
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Ruthana date extract inhibited proliferation of human hepatocellular carcinoma (HepG2) cells by modulation of BAX gene
Cancer response to chemotherapeutic agents and its side effects remain a challenge for the development of new anticancer compounds. Dates are...
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Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some...
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The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy
BackgroundAs a progesterone receptor antagonist, mifepristone combined with misoprostol is widely used to terminate early pregnancy in clinical...
