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The new Systematic Coronary Risk Evaluation (SCORE2 and SCORE2-OP) estimates the risk of arterial occlusive events in chronic myeloid leukemia patients treated with nilotinib or ponatinib
Patients with chronic myeloid leukemia (CML) treated with nilotinib or ponatinib may experience arterial occlusive events (AOEs). It is currently...
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Anticoagulants
Anticoagulants and antithrombotic drugs are among the most frequently prescribed drugs. In the last 20 years, new drug classes have emerged, which...
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Purpuras
Purpura results from coalesced petechia, which are small (≤4 mm), flat, red, discrete areas of the skin due to erythrocyte extravasation, which can...
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Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
Purpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately...
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Antiplatelet and Anticoagulant Therapy in Interventional Pain Management
Managing antithrombotic and antiplatelet therapy is one of the common issues while performing interventional techniques to balance the bleeding risk...
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Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction
BackgroundNumerous drugs have the potential to be affected by cytochrome P450 (CYP) 2B6-mediated drug–drug interactions (DDIs).
Objectives ...
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Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes
Background and ObjectivesBoth AW-9A (coumarin derivative) and WES-1 (sulfonamide derivative) were designed and synthesized as potential selective...
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Clopidogrel-induced neutropenia in an 80-year-old patient with chronic kidney disease who underwent percutaneous coronary intervention: a case report and literature review
BackgroundClopidogrel is a widely-used antiplatelet and acts as an adenosine diphosphate receptor inhibitor. Neutropenia is a rare but serious...
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Oxidative stress and its role in Fabry disease
Fabry disease is a rare X-linked disease characterized by deficient expression and activity of alpha-galactosidase A with consequent lysosomal...
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Antiplatelet and Anticoagulant Therapy in Regenerative Medicine
Managing antithrombotic and antiplatelet therapy is one of the common issues while performing interventional techniques in regenerative medicine to...
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A registry study of Kawasaki disease patients with coronary artery aneurysms (KIDCAR): a report on a multicenter prospective registry study three years after commencement
The long-term prognosis of patients with Kawasaki disease (KD) complicated by coronary artery aneurysms (CAA) is still unclear. The present,...
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Phenytoin
The effect of analgesics, antibacterials, antifungal agents, antineoplastic agents, antituberculous agents, antiulcer drugs, antiviral agents,...
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Methadone
Methadone is an opioid with the longest elimination half life in the clinical practice of anesthesia. Traditionally used in oral form for the purpose...
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Discharge of Acute Coronary Syndrome Patients on Sub-Optimal Dual Anti-Platelet Therapy: A Single Center Experience
PurposeTo identify and quantify the reasons why acute coronary syndrome (ACS) patients undergoing stenting at the University of New Mexico Hospital...
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Outcomes of patients with cerebral microbleeds undergoing percutaneous coronary intervention and dual antiplatelet therapy
Introduction: Cerebral microbleeds (CMBs) on brain magnetic resonance imaging (MRI) are predictive of intracerebral hemorrhage (ICH). However, the...
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Thrombosis, Hemostasis, and Cardiovascular Outcomes
Venous and arterial thromboembolism accounts for one of the highest burdens of cardiovascular morbidity and mortality. Appropriate and timely...
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Pharmacokinetic Studies for Drug Development
This chapter introduces investigators to the role of pharmacokinetics (PK) and toxicokinetics (TK) play in drug development. The chapter describes...