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Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade
BackgroundMutations in BRCA1 or BRCA2 ( BRCA1/2 ) cause homologous recombination deficiency (HRD). Ovarian cancer (OvCa) patients harbouring HRD...
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Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern
Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer’s disease, closely related to cognitive dysfunction and...
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Overview of Clinically Available Radiotracers for Imaging in Neurodegenerative Disorders
Well-designed radiotracers for molecular imaging are powerful tools for the investigation of neurodegenerative disorders and for providing new means...
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PET Quantification and Kinetic Analysis
The use of radiopharmaceuticals and the imaging of their kinetics are key components to successful developments in PET. The state-of-the-art PET...
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Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
BackgroundProgression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein...
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The impact of brivaracetam on cognitive processes and anxiety in various experimental models
BackgroundMemory deficits and anxiety symptoms are undesirable effects that occur in epilepsy patients. They may be associated with the...
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Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with 18F-SynVesT-1 positron emission tomography imaging
PurposeThe loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia...
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Anti-convulsant Agents: Levetiracetam and Brivaracetam
Levetiracetam (LEV) and brivaracetam (BRV) are pyrrolidone derivate compounds binding at the presynaptic SV2A receptor site and thus representing...
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The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain
BackgroundPositron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [ 18 F]UC...
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Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies....
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Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A)
PurposeSynaptic abnormalities have been implicated in a variety of neuropsychiatric disorders, including epilepsy, Alzheimer’s disease, and...
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Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J
BackgroundAttempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small...
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Deep phenoty** towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
BackgroundMajor Depressive Disorder (MDD) is a heterogenous brain disorder, with potentially multiple psychosocial and biological disease mechanisms....
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Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) is a hexanucleotide repeat expansion within...
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Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns
BackgroundThe synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle...
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Lower synaptic density is associated with psychiatric and cognitive alterations in obesity
Obesity is a serious medical condition that often co-occurs with stress-related psychiatric disorders. It is recognized that the brain plays a key...
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Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour
BackgroundCurrently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging....
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Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
Synaptic vesicles are storage organelles for neurotransmitters. They pass through a trafficking cycle and fuse with the pre-synaptic membrane when an...
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Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular and cellular mechanisms...
