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The novel cytotoxic polybisphosphonate osteodex decreases bone resorption by enhancing cell death of mature osteoclasts without affecting osteoclastogenesis of RANKL-stimulated mouse bone marrow macrophages
It has previously been demonstrated that the polybisphosphonate osteodex (ODX) inhibits bone resorption in organ-cultured mouse calvarial bone. In...
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CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury
In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of...
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RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway
Prostate cancer (PCa) morbidity in the majority of patients is due to metastatic events, which are a clinical obstacle. Therefore, a better...
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Association Between Serum Selenium Concentration and OPG/RANKL/RANK Axis in Patients with Arterial Hypertension
The aim of the study was to determine the relationship between the serum selenium concentration (Se–S) and the blood concentrations of...
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Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways
BackgroundPostmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast formation and function. Targeting osteoclast...
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RANK/RANKL/OPG axis genes relation to cognitive impairment in children with transfusion-dependent thalassemia: a cross-sectional study
BackgroundRANK/RANKL/OPG axis was implicated in many pathological conditions. The study aimed to assess the relationship between the studied RANK,...
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IL-6 promotes low concentration of RANKL-induced osteoclastic differentiation by mouse BMMs through trans-signaling pathway
The exact role of IL-6 in inflammatory osteoclast formation is still under debate. Our previous study demonstrated that IL-6 in the combination of...
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Fractionated whole body γ-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative potential of ebselen
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease associated with oxidative stress that causes excruciating pain, discomfort,...
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Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis
BackgroundPhosphorylation modification of BCL2 is involved in receptor activator of nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast...
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Immunohistochemical analysis of the distribution of RANKL: a case of disseminated carcinomatosis of bone marrow as the first presentation of relapse in curatively resected colorectal cancer
Poorly differentiated adenocarcinoma of colorectal carcinoma (CRC) is a rare condition with poor prognosis. In this report, we describe a case of a...
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Inhibition of RANKL and Sema4D improves residual ridge resorption in mice
Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments...
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Nacre-mimetic cerium-doped nano-hydroxyapatite/chitosan layered composite scaffolds regulate bone regeneration via OPG/RANKL signaling pathway
Autogenous bone grafting has long been considered the gold standard for treating critical bone defects. However, its use is plagued by numerous...
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RANKL regulates male reproductive function
Infertile men have few treatment options. Here, we demonstrate that the transmembrane receptor activator of NF-kB ligand (RANKL) signaling system is...
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Sophoraflavanone G Inhibits RANKL-Induced Osteoclastogenesis via MAPK/NF-κB Signaling Pathway
Osteoporosis is a common chronic bone metabolism disorder characterized by decreased bone mass and reduced bone density in the bone tissue....
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The expression levels of MicroRNA-146a, RANKL and OPG after non-surgical periodontal treatment
ObjectiveMicroRNA-146a (miR-146a) is a regulator of inflammatory response. Periodontitis is a disease with immune pathophysiology of the periodontium...
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Yangonin treats inflammatory osteoporosis by inhibiting the secretion of inflammatory factors and RANKL expression
ObjectivesAs the main cause of osteoporosis, abnormal activity of osteoclasts could disrupt the balance between bone resorption and formation....
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Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption
Brevilin A (BA) is the primary component of Centipeda minima , which is widely used in Chinese traditional medicine. The anti-inflammatory and...
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Phase I, Randomized, Placebo-Controlled, Dose-Escalation Study of GB223, a Fully-Humanized Monoclonal Antibody to RANKL, in Healthy Chinese Adults
BackgroundGB223 is a novel, fully-humanized monoclonal antibody against the receptor activator of nuclear factor-kappa B ligand (RANKL). In this...
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Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction
Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated...
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Age-related changes and reference intervals of RANKL, OPG, and bone turnover markers in Indian women
SummaryRANKL and OPG are cytokines involved in bone remodeling that makes them potential bone biomarkers. The reference interval for these cytokines,...