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Genome-Wide Young L1 Methylation Profiling by bs-ATLAS-seq
By silencing L1 retrotransposons, DNA methylation protects mammalian genomes from potent endogenous mutagens. However, some loci can escape this...
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Degradation of methylation signals in cryopreserved DNA
BackgroundBlood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often...
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Roles and Regulation of H3K4 Methylation During Mammalian Early Embryogenesis and Embryonic Stem Cell Differentiation
From generation of germ cells, fertilization, and throughout early mammalian embryonic development, the chromatin undergoes significant alterations...
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DNA Methylation in Experimental Ischemic Brain Injury
The enrichment of angioneurology with fundamental achievements is leading to an understanding of new important aspects of the pathogenesis of...
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Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features
BackgroundAberrant DNA methylation occurs commonly during pathogenesis of neuroimmunological diseases and is of clinical value in various...
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Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure
Obesity is defined by increased adipose tissue volume and has become a major risk factor for reproduction. Recent studies have revealed a substantial...
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DNA Methylation and Epigenetic Aging Biomarkers in Huntington’s Disease
DNA methylation is an epigenetic modification that plays critical roles in several important processes, including regulation of transcription,...
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The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter region
Avian leukosis virus subgroup J (ALV-J) can cause neoplastic diseases in poultry and is still widely prevalent in China. Chicken telomerase reverse...
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Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study
To explore the association between methylation level and transcript level of TNF receptor-associated factor 5 (TRAF5) gene with ankylosing...
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Role of Silicon in Mediating Salt Stress Responses in Arabidopsis Methylation Mutants
PurposeThe growing prevalence of soil salinity presents a significant threat to agriculture production on a global scale. Previous studies on salt...
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DNA Methylation in Aortic Aneurysms of Different Localizations
Abstract—Aortic aneurysm (AA) is a life-threatening condition, and aortic rupture that is the complication of AA in the absence of emergency surgery...
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H3K36 methylation maintains cell identity by regulating opposing lineage programmes
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a...
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DNA Methylation in the Adaptive Response to Exercise
Emerging evidence published over the past decade has highlighted the role of DNA methylation in skeletal muscle function and health, including as an...
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Curcumin leads to responses of grapes to aluminum stress by inducing whole genome hypo-methylation
Aluminum (Al) is the most abundant element in the earth crust. Due to the abuse of phosphate fertilizer, acid rain has been frequently observed in...
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Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion
BackgroundDNA methylation is a critical molecular mark involved in cellular differentiation and cell-specific processes. Single-cell whole genome DNA...
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PLK1 maintains DNA methylation and cell viability by regulating phosphorylation-dependent UHRF1 protein stability
PLK1 is a key serine/threonine kinase as well as a master mitotic regulator, but it has never been reported that PLK1 regulates DNA methylation. In...
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Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The...
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DNA methylation in poultry: a review
As an important epigenetic modification, DNA methylation is involved in many biological processes such as animal cell differentiation, embryonic...
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Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence
BackgroundSerotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other...
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Inhibitors of DNA Methylation
DNA methylation is involved in numerous biological processes and is deregulated in human diseases. The modulation of the activity of the enzymes and...