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A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity
Re-activating quiescent adult epicardium represents a potential therapeutic approach for human cardiac regeneration. However, the exact molecular...
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Role of PARP1 on DNA damage induced by mineral silicate chrysotile in bronchial epithelial and pleural mesothelial cells
To investigate whether poly (ADP ribose) polymerase-1 (PARP1) is involved in chrysotile-induced DNA damage in pleural mesothelial cells (MeT-5A) and...
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Asiaticoside inhibits TGF-β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5
BackgroundPeritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). Peritoneal mesothelial cells (PMCs), the first...
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EPAS1 promotes peritoneal carcinomatosis of non-small-cell lung cancer by enhancing mesothelial–mesenchymal transition
BackgroundNon-small-cell lung cancer (NSCLC) is a major cause of cancer-related death globally. Endothelial PAS domain-containing protein 1 (EPAS1)...
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A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
To understand functional duality of the complement system in host defense and lung injury, a more comprehensive view of its localized production in...
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Single-cell transcriptomic analysis of endometriosis
Endometriosis is a common condition in women that causes chronic pain and infertility and is associated with an elevated risk of ovarian cancer. We...
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Engineering Approaches in Ovarian Cancer Cell Culture
Determination of the frequency of somatic mutations, copy number variations, and the composition of single-nucleus transcriptomes in epithelial...
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Anatomical Structure of the Pleura and Mesothelial Cells: What Are the Characteristic Features?
It is important to understand the anatomy of the visceral and parietal pleura for an accurate pathological diagnosis of malignant mesothelioma....
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BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation
BackgroundMalignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid...
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Cell-free DNA methylation analysis as a marker of malignancy in pleural fluid
Diagnosis of malignant pleural effusion (MPE) is made by cytological examination of pleural fluid or histological examination of pleural tissue from...
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Exploring the histogenesis of STK11 adnexal tumour using electron microscopy
STK11 adnexal tumour is a recently described female genital tract tumour, usually identified in a paratubal location, often associated with...
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Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport
Next to the skin, the peritoneum is the largest human organ, essentially involved in abdominal health and disease states, but information on...
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Cellular and molecular events of inflammation induced transdifferentiation (EMT) and regeneration (MET) in mesenteric mesothelial cells
In this review we summarize the cellular and molecular events of inflammation induced epithelial-to-mesenchymal (EMT) and mesothelial-to-macrophage...
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Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
BackgroundAsthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with...
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Mesothelioma: morphologic and immunohistochemical findings
This paper reviews some basic and some new concepts in the diagnosis of mesothelioma. The term “malignant mesothelioma” is no longer recommended;...
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Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis
Despite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding as to how biomechanical signals are...
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Peritoneal Structure and Changes as a Dialysis Membrane After Peritoneal Dialysis
In this chapter, the purpose of the authors and editors is to review and concentrate the incomparable information included in the 3rd edition of this...
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Monitoring the Functional Status of the Peritoneum
In this chapter information is given on what can be monitored of the peritoneal membrane. First the various aspects of mesothelial cell markers are...
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Gastric cancer cell-derived extracellular vesicles elevate E2F7 expression and activate the MAPK/ERK signaling to promote peritoneal metastasis through the delivery of SNHG12
Cancer cell-derived extracellular vesicles (EVs) have extensive application in the formation of their environment, including metastasis. This study...
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Immune cell identifier and classifier (ImmunIC) for single cell transcriptomic readouts
Single cell RNA sequencing has a central role in immune profiling, identifying specific immune cells as disease markers and suggesting therapeutic...
