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Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or...
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Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis
Preventing or effectively treating metastatic uveal melanoma (UM) is critical because it occurs in about half of patients and confers a very poor...
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RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma
The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME), and insufficient activation of...
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Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
Epacadostat (EPA), the most advanced IDO1 inhibitor, in combination with PD-1 checkpoint inhibitor, has failed in a recent Phase III clinical trial...
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SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation
Melanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted...
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Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance
Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and...
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Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition
Immunotherapies, including immune checkpoint inhibitors, have limitations in their effective treatment of malignancies. The immunosuppressive...
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Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells
The protocadherin proteins are cell adhesion molecules at the crossroad of signaling pathways playing a major role in neuronal development. It is now...
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Dynamic thresholding and tissue dissociation optimization for CITE-seq identifies differential surface protein abundance in metastatic melanoma
Multi-omics profiling by CITE-seq bridges the RNA-protein gap in single-cell analysis but has been largely applied to liquid biopsies. Applying...
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Multi-modal molecular programs regulate melanoma cell state
Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic...
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VEGF-A promotes the motility of human melanoma cells through the VEGFR1–PI3K/Akt signaling pathway
Vascular endothelial growth factor A (VEGF-A) and its receptors (VEGFR1 and R2) play important roles in the progression of malignant melanoma through...
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Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also...
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The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma
Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as...
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Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity
BackgroundMelanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the...
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Enhancement of anti-tumor activity in melanoma using arginine deiminase fused with 30Kc19α protein
AbstractArginine deiminase (ADI) is a microbial-derived enzyme which catalyzes the conversion of l -arginine into l -citrulline. ADI originating from Mycoplasma...
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Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma
The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most...
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Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
Originally considered to act as a transcriptional co-factor, Pirin has recently been reported to play a role in tumorigenesis and the malignant...
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Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients
BackgroundNivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are...
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Hyaluronic acid-antigens conjugates trigger potent immune response in both prophylactic and therapeutic immunization in a melanoma model
Immunotherapy of advanced melanoma has encountered significant hurdles in terms of clinical efficacy. Here, we designed a clinically translatable...
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Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy
BackgroundMetastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the...
