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Posttranscriptional Regulation by Proteins and Noncoding RNAs
Posttranscriptional regulation comprises those mechanisms occurring after the initial copy of the DNA sequence is transcribed into an intermediate...
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LncRNA H19 Regulates P-glycoprotein Expression Through the NF-κB Signaling Pathway in the Model of Status Epilepticus
Pharmaco-resistance is a challenging problem for treatment of status epilepticus (SE) in the clinic. P-glycoprotein (P-gp) is one of the most...
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Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells
Hypoxia is a classic feature of the tumor microenvironment that has profound effects on cancer progression and is tightly associated with poor...
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Cerebellar Long Noncoding RNA Expression Profile in a Niemann-Pick C Disease Mouse Model
Niemann-Pick type C (NP-C) disease is a neurodegenerative lysosomal storage disorder primarily caused by mutations in NPC1 . However, its pathogenesis...
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Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis
Doxorubicin (DOX) is an efficacious and widely used drug for human malignancy treatment, but its clinical application is limited due to side effects,...
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Long noncoding RNA XLOC_006786 inhibits the proliferation, invasion and metastasis of osteosarcoma cells through NOTCH3 signaling pathway by targeting miR-491-5p
Recent research has indicated that Long noncoding RNAs (LncRNAs) are crucial in many disorders, especially tumors. However, the exact role of LncRNA...
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The role of long noncoding ribonucleic acids in the central nervous system injury
Central nervous system (CNS) injury involves complex pathophysiological molecular mechanisms. Long noncoding ribonucleic acids (lncRNAs) are an...
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Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway
BackgroundLong non-coding RNA (lncRNA) H19 is one of the most highly expressed and conserved transcripts in mammalian development, and its functions...
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H19 may regulate the immune cell infiltration in carcinogenesis of gastric cancer through miR-378a-5p/SERPINH1 signaling
BackgroundIncreasing studies have indicated that noncoding RNA (ncRNA)-mediated competing endogenous RNA (ceRNA) network serves as a significant role...
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Noncoding RNA regulation and Oxidative Stress
Carcinogenesis is a multistep process involving genetic, epigenetic, transcriptomic and proteomic changes that slowly but steadily transform healthy...
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Noncoding RNA regulation and Oxidative Stress
Carcinogenesis is a multistep process involving genetic, epigenetic, transcriptomic and proteomic changes that slowly but steadily transform healthy...
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H19 encourages aerobic glycolysis and cell growth in gastric cancer cells through the axis of microRNA-19a-3p and phosphoglycerate kinase 1
Numerous studies have been conducted on long non-coding RNAs (lncRNAs) in human tumors like gastric cancer (GC). Our research uncovers how aerobic...
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Long noncoding RNA HOTAIR promotes breast cancer development through the lncRNA HOTAIR/miR-1/GOLPH3 axis
BackgroundThe lncRNA HOTAIR is frequently overexpressed in breast cancer tissues and plays an important role in the development of breast cancer....
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LncRNA H19 Participates in Leukemia Inhibitory Factor Mediated Stemness Promotion in Colorectal Cancer Cells
Colorectal cancer (CRC) is a common human malignancy and the third leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) were...
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Roles of long noncoding RNAs in human inflammatory diseases
Chemokines, cytokines, and inflammatory cells mediate the onset and progression of many diseases through the induction of an inflammatory response....
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H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-22-3p
A great number of studies have confirmed that long noncoding RNA (lncRNA) are involved in the regulation of inflammatory response in acute gouty...
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Research updates on the clinical implication of long noncoding RNA in digestive system cancers and chemoresistance
Long noncoding RNAs (lncRNAs) are implicated in various biological processes, such as cell proliferation, differentiation, apoptosis, migration, and...
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Long Noncoding RNAs: An Overview
Recently an explosion in the discovery of long noncoding RNAs (lncRNAs)Long noncoding RNAs (LncRNAs) was obtained by high-throughput...
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Long noncoding RNAs: glycolysis regulators in gynaecologic cancers
The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial...
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Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p
BackgroundPatients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical...
