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Transplant Infectious Disease Evaluation of Cytopenias
Cytopenias are a common occurrence in both hematopoietic stem cell and solid organ transplant recipients, particularly in the early post-transplant...
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Herpes Simplex Viruses 1 and 2, Varicella Zoster Virus, and Human Herpes Viruses 6, 7, and 8 in Transplant Recipients
Human herpes viruses are a family of double-stranded DNA viruses that cause opportunistic infections in solid organ and hematopoietic stem cell...
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Multi-pathogen infections and Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and...
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Maternal natural killer cells at the intersection between reproduction and mucosal immunity
Many maternal immune cells populate the decidua, which is the mucosal lining of the uterus transformed during pregnancy. Here, abundant natural...
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Infections in Immunosuppressed Pediatric Patients
Infections are an important cause of morbidity and mortality in children undergoing treatment for cancer. Up to two-thirds of toxic deaths during...
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Chromosomal Integration by Human Herpesviruses 6A and 6B
Upon infection and depending on the infected cell type, human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) can replicate or enter a state of latency....
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Antiviral Therapies: A Critical Reappraisal
Myocarditis is frequently associated with viral infections, a scenario that can progress to cardiomyopathy and sudden cardiac death. Viral infections...
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High-resolution profiling of human cytomegalovirus cell-free DNA in human plasma highlights its exceptionally fragmented nature
Human cytomegalovirus (CMV) infections comprise a leading cause of newborn impairments worldwide and are pervasive concerns among the...
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Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection
Respiratory tract infections (RTI) can take a serious course under immunosuppression. Data on the impact of the underlying pathogens are still...
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Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society for Hematopoietic Cell Transplantation
Reactivation of human herpesvirus (HHV)-6B is relatively common after allogeneic hematopoietic stem cell transplantation (HSCT) and HHV-6B diseases...
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The Role of Viruses in the Genesis of Hodgkin Lymphoma
Hodgkin lymphoma is a heterogeneous condition. A proportion of cases of classic Hodgkin lymphoma are associated with the Epstein-Barr virus (EBV), a...
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Molecular Diagnostics in Central Nervous System Infections
Central nervous system (CNS) infections can be life threatening if not diagnosed and treated early. The myriad clinical presentations of CNS...
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A tissue level atlas of the healthy human virome
BackgroundHuman-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing technology has...
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The human vascular endothelial cell line HUV-EC-C harbors the integrated HHV-6B genome which remains stable in long term culture
Human herpes virus 6 (HHV-6) is a common human pathogen that is most often detected in hematopoietic cells. Although human cells harboring...
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Transplant Infectious Disease Evaluation of Cytopenias
Cytopenias are a common occurrence in both hematopoietic stem cell and solid organ transplant recipients, particularly in the early post-transplant...
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Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6
BackgroundHuman herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human...
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BMT Settings, Infection and Infection Control
Despite improvements over the past several decades, infection remains a significant risk to all haematological patients receiving therapy. Those...
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HHV-6A infection induces amyloid-beta expression and activation of microglial cells
BackgroundThe control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly...
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Genetic Basis of Myocarditis: Myth or Reality?
The genetic basis of myocarditis remains an intriguing concept, at least as long as the definition of myocarditis constitutes the definitive presence...
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Severe Infections of the Central Nervous System
Early recognition of an infectious syndrome and initiation of appropriate treatment improves outcome. Yet, in spite of advances in diagnosis and...