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Screening and Identification of a Specific Binding Peptide to Ovarian Cancer Cells from a Phage-Displayed Peptide Library
To select specific binding peptides for imaging and detection of human ovarian cancer. The phage 12-mer peptide library was used to select specific...
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Preparation and interaction mechanism analysis of single-chain fragment variables against phenylethanolamine A
This is the first report on the screening, expression, and recognition mechanism analysis of single-chain fragment variable (scFv) against...
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Identification of COVID-19 B-cell epitopes with phage-displayed peptide library
BackgroundCoronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the...
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Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment
In the rapidly advancing field of synthetic biology, there exists a critical need for technology to discover targeting moieties for therapeutic...
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Engineering of SH2 Domains for the Recognition of Protein Tyrosine O-Sulfation Sites
Protein engineering has brought advances to industrial processes, biomaterials, nanotechnology, biosensors, and biomedical applications. This chapter...
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Application of Phage-Displayed Peptides in Tumor Imaging Diagnosis and Targeting Therapy
Phage display is an effective and powerful technique that provides a route to discovery unique peptides targeting to tumor cells. Specifically...
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Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires
Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired...
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Isolation and characterizations of a novel recombinant scFv antibody against exotoxin A of Pseudomonas aeruginosa
BackgroundPseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting...
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Phage Display Technique as a Tool for Diagnosis and Antibody Selection for Coronaviruses
Phage display is one of the important and effective molecular biology techniques and has remained indispensable for research community since its...
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M13 phage: a versatile building block for a highly specific analysis platform
Viruses are changing the biosensing and biomedicine landscape due to their multivalency, orthogonal reactivities, and responsiveness to genetic...
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An effective antibiofilm strategy based on bacteriophages armed with silver nanoparticles
The emerging antibiotic resistance in pathogenic bacteria is a key problem in modern medicine that has led to a search for novel therapeutic...
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Phage Display of Bovine Ultralong CDRH3
Phage display is an in vitro technique used in the discovery of monoclonal antibodies that has been used successfully in the discovery of both...
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New carbohydrate binding domains identified by phage display based functional metagenomic screens of human gut microbiota
Uncultured microbes represent a huge untapped biological resource of novel genes and gene products. Although recent genomic and metagenomic...
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Isolation of Adhirons Specific for Plant Protoplast Membrane Biomarkers Is Simplified by Phagemid Design
Phage display is an effective method to retrieve binders specific for a target epitope from a large clone library. Nevertheless, the panning process...
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Neutralizing anti-diphtheria toxin scFv produced by phage display
BackgroundDiphtheria can be prevented by vaccination, but some epidemics occur in several places, and diphtheria’s threat is considerable....
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Generation of peptides using phage display technology for cancer diagnosis and molecular imaging
Cancer is one of the leading causes of mortality worldwide; nearly 10 million people died from it in 2020. The high mortality rate results from the...
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Phage Display Technology and the Development of Phage-Based Vaccines
A great many phages are amenable to a range of common genetic manipulations. They are also easy to propagate to high numbers and simple to handle....
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Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides
Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity macrocyclic peptide ligands for therapeutic...
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Identification of a novel peptide ligand for the cancer-specific receptor mutation EGFRvIII using high-throughput sequencing of phage-selected peptides
We report here the selection and characterization of a novel peptide ligand using phage display targeted against the cancer-specific epidermal growth...
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Extensive antibody search with whole spectrum black-box optimization
In designing functional biological sequences with machine learning, the activity predictor tends to be inaccurate due to shortage of data. Top ranked...
