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Exploration of subtype-specific perturbations in breast cancer
Breast cancer remains a leading cause of mortality among women, characterized by its complex and diverse nature, comprising various molecular...
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Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum
Dengue fever cases are spiking over the last two decades. Incessant efforts are still being made to gain deeper insights on this arboviral disease...
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Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro
Lung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell...
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Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration
BackgroundIntervertebral disc degeneration (IDD) has become a serious public health problem, the mechanism of which is complex and still unclear. We...
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A human stomach cell type transcriptome atlas
BackgroundThe identification of cell type-specific genes and their modification under different conditions is central to our understanding of human...
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Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Currently, overcoming the drug resistance in HCC is a...
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Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution
Following prolonged cell division, mesenchymal stem cells enter replicative senescence, a state of permanent cell cycle arrest that constrains the...
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Cloning, Expression, and Purification of the Human Synthetic Survivin Protein in Escherichia coli Using Response Surface Methodology (RSM)
Survivin is one of the novel members of the apoptosis inhibitor protein family in humans. The main activity of the Survivin protein is to suppress...
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Exploring the mechanism and experimental verification of puerarin in the treatment of endometrial carcinoma based on network pharmacology and bioinformatics analysis
Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent years. In the light of many controversies about its...
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Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death
In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human...
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Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231
Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer...
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New insights into the ambivalent role of YAP/TAZ in human cancers
Hippo signaling was first identified in Drosophila as a key controller of organ size by regulating cell proliferation and anti-apoptosis. Subsequent...
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Emerging functions and significance of circCDYL in human disorders
Circular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central...
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Runt-related transcription factors in human carcinogenesis: a friend or foe?
PurposeCancer is one of the deadliest pathologies with more than 19 million new cases and 10 million cancer-related deaths across the globe. Despite...
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Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice
BackgroundCDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during...
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GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
BackgroundG protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR...
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Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis
The kidney is a complex organ composed of more than 30 terminally differentiated cell types that all are required to perform its numerous homeostatic...
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New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone
In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen) 2 (xant)](PF 6 ) (RXC), that can eliminate colorectal cancer (CRC) stem cells...
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A co-formulation of interferons alpha2b and gamma distinctively targets cell cycle in the glioblastoma-derived cell line U-87MG
BackgroundHeberFERON is a co-formulation of α2b and γ interferons, based on their synergism, which has shown its clinical superiority over individual...
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Bioinformatic analysis highlights SNHG6 as a putative prognostic biomarker for kidney renal papillary cell carcinoma
PurposeKidney renal papillary cell carcinoma (KIRP) is a highly heterogeneous malignancy and current systemic therapeutic strategies are difficult to...
